Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy

被引：2
作者：
Khan, Ziauddin [1 ,2 ]
Ahmad, Suhail [1 ]
Mokaddas, Eiman [1 ,3 ]
Meis, Jacques F. [4 ,5 ]
Joseph, Leena [1 ]
Abdullah, Aneesa [3 ]
Vayalil, Sandhya [2 ]
机构：
[1] Kuwait Univ, Dept Microbiol, Fac Med, Jabriya, Kuwait
[2] Mubarak Al Kabeer Hosp, Mycol Reference Lab, Jabriya, Kuwait
[3] Ibn Sina Hosp, Dept Lab Med, Kuwait, Kuwait
[4] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
[5] Ctr Expertise Mycol Radboudumc, Canisius Wilhelmina Hosp, Nijmegen, Netherlands
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 04期
关键词：
Candida tropicalis; echinocandins; FKS1; mutations; primary resistance; genotyping; MULTIDRUG-RESISTANCE; TIME-KILL; FKS1; GENE; MICAFUNGIN; MUTATIONS; GLABRATA; MULTICENTER; EMERGENCE; ALBICANS; KRUSEI;
D O I：
10.1128/AAC.01926-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Isolation of two echinocandin-resistant Candida tropicalis strains from endotracheal secretions of a patient following short-term exposure to caspofungin is described. Both strains exhibited resistance to echinocandins by Etest and reference broth microdilution, showing a homozygous S645P mutation within the hot spot 1 (HS-1) region of FKS1 and belonging to a unique multilocus sequence type. Other C. tropicalis isolates collected from patients in the same intensive care unit within a 60-day period were susceptible to echinocandins and contained wild-type FKS1 sequences.
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页数：7
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共 46 条
  • [1] Population structure and molecular genetic characterization of clinical Candida tropicalis isolates from a tertiary-care hospital in Kuwait reveal infections with unique strains
    Al-Obaid, Khaled
    Asadzadeh, Mohammad
    Ahmad, Suhail
    Khan, Ziauddin
    [J]. PLOS ONE, 2017, 12 (08):
  • [2] [Anonymous], 2008, Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts
  • [3] Third Informational Supplement. CLSI document M27-S3, P28
  • [4] [Anonymous], 2012, M27S4 CLSI
  • [5] Echinocandin resistance: an emerging clinical problem?
    Arendrup, Maiken C.
    Perlin, David S.
    [J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2014, 27 (06) : 484 - 492
  • [6] Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
    Arendrup, Maiken Cavling
    Patterson, Thomas F.
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2017, 216 : S445 - S451
  • [7] Echinocandin Susceptibility Testing of Candida Species: Comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, Disk Diffusion, and Agar Dilution Methods with RPMI and IsoSensitest Media
    Arendrup, Maiken Cavling
    Garcia-Effron, Guillermo
    Lass-Floerl, Cornelia
    Gomez Lopez, Alicia
    Rodriguez-Tudela, Juan-Luis
    Cuenca-Estrella, Manuel
    Perlin, David S.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (01) : 426 - 439
  • [8] Antifungal susceptibility of clinical Candida parapsilosis isolates in Kuwait
    Asadzadeh, Mohammad
    Al-Sweih, Noura A.
    Ahmad, Suhail
    Khan, Zia U.
    [J]. MYCOSES, 2008, 51 (04) : 318 - 323
  • [9] Population structure and molecular genetic characterization of 5-flucytosine-susceptible and -resistant clinical Candida dubliniensis isolates from Kuwait
    Asadzadeh, Mohammad
    Ahmad, Suhail
    Al-Sweih, Noura
    Khan, Ziauddin
    [J]. PLOS ONE, 2017, 12 (04):
  • [10] Epidemiological trends in nosocomial candidemia in intensive care
    Bassetti, M
    Righi, E
    Costa, A
    Fasce, R
    Molinari, MP
    Rosso, R
    Pallavicini, FB
    Viscoli, C
    [J]. BMC INFECTIOUS DISEASES, 2006, 6 (1)
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