Caspase activity sows the seeds of neuronal death

被引：32

作者：

Yuan, JY

Yankner, BA

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[3] Childrens Hosp, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1038/10037

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caspases, proteases involved in programmed cell death, may have a role in Alzheimer's and Huntington's diseases. Localized caspase activation and apoptosis may be linked to the initiation of such chronic neurodegenerative diseases.

引用

页码：E44 / E45

页数：2

共 15 条

[1] RELEASE OF EXCESS AMYLOID BETA-PROTEIN FROM A MUTANT AMYLOID BETA-PROTEIN PRECURSOR [J].

CAI, XD ;

GOLDE, TE ;

YOUNKIN, SG .

SCIENCE, 1993, 259 (5094) :514-516

[2] EXCESSIVE PRODUCTION OF AMYLOID BETA-PROTEIN BY PERIPHERAL CELLS OF SYMPTOMATIC AND PRESYMPTOMATIC PATIENTS CARRYING THE SWEDISH FAMILIAL ALZHEIMER-DISEASE MUTATION [J].

CITRON, M ;

VIGOPELFREY, C ;

TEPLOW, DB ;

MILLER, C ;

SCHENK, D ;

JOHNSTON, J ;

WINBLAD, B ;

VENIZELOS, N ;

LANNFELT, L ;

SELKOE, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) :11993-11997

[3] MUTATION OF THE BETA-AMYLOID PRECURSOR PROTEIN IN FAMILIAL ALZHEIMERS-DISEASE INCREASES BETA-PROTEIN PRODUCTION [J].

CITRON, M ;

OLTERSDORF, T ;

HAASS, C ;

MCCONLOGUE, L ;

HUNG, AY ;

SEUBERT, P ;

VIGOPELFREY, C ;

LIEBERBURG, I ;

SELKOE, DJ .

NATURE, 1992, 360 (6405) :672-674

[4] Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation [J].

Gervais, FG ;

Xu, DG ;

Robertson, GS ;

Vaillancourt, JP ;

Zhu, YX ;

Huang, JQ ;

LeBlanc, A ;

Smith, D ;

Rigby, M ;

Shearman, MS ;

Clarke, FE ;

Zheng, H ;

Van Der Ploeg, LHT ;

Ruffolo, SC ;

Thornberry, NA ;

Xanthoudakis, S ;

Zamboni, RJ ;

Roy, S ;

Nicholson, DW .

CELL, 1999, 97 (03) :395-406

[5] Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract [J].

Goldberg, YP ;

Nicholson, DW ;

Rasper, DM ;

Kalchman, MA ;

Koide, HB ;

Graham, RK ;

Bromm, M ;

KazemiEsfarjani, P ;

Thornberry, NA ;

Vaillancourt, JP ;

Hayden, MR .

NATURE GENETICS, 1996, 13 (04) :442-449

[6] β-amyloid induces local neurite degeneration in cultured hippocampal neurons:: Evidence for neuritic apoptosis [J].

Ivins, KJ ;

Bui, ETN ;

Cotman, CW .

NEUROBIOLOGY OF DISEASE, 1998, 5 (05) :365-378

[7]

Jordan J, 1997, J NEUROCHEM, V68, P1612

[8]

LeBlanc A, 1995, J NEUROSCI, V15, P7837

[9] Evidence for synaptic apoptosis [J].

Mattson, MP ;

Keller, JN ;

Begley, JG .

EXPERIMENTAL NEUROLOGY, 1998, 153 (01) :35-48

[10]

ONA VO, IN PRESS NATURE

← 1 2 →