Transition metal-free synthesis of α-aryl ketones via oxyallyl cation capture with arylboronic acids

被引：12

作者：

Huang, Wei-Hua ^{[1
]}

Huang, Gong-Bin ^{[1
]}

Zhu, Wen-Run ^{[1
]}

Weng, Jiang ^{[1
]}

Lu, Gui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 17期

基金：

中国国家自然科学基金;

关键词：

4+3 CYCLOADDITION REACTION; CROSS-COUPLINGS; BORONIC ACIDS; ARYLATION; INTERMEDIATE; CARBON; FUNCTIONALIZATION; ACTIVATION; REACTIVITY; FLUORINE;

D O I：

10.1039/d0qo00447b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe a novel transition metal-free, umpolung strategy for the alpha-arylation of ketones by capturing transient oxyallyl cations with arylboronic acids. A variety of alpha-arylated ketones were obtained in moderate to good yields with broad substrate tolerance under simple reaction conditions. This process provides a complementary strategy compared with traditional transition metal-catalyzed methods.

引用

页码：2480 / 2485

页数：6

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