Anthropometric and Hormonal Risk Factors for Male Breast Cancer: Male Breast Cancer Pooling Project Results

被引：100

作者：

Brinton, Louise A. ^{[1
]}

Cook, Michael B. ^{[1
]}

McCormack, Valerie ^{[2
]}

Johnson, Kenneth C. ^{[3
]}

Olsson, Hakan ^{[4
]}

Casagrande, John T. ^{[5
]}

Cooke, Rosie ^{[6
]}

Falk, Roni T. ^{[1
]}

Gapstur, Susan M. ^{[7
]}

Gaudet, Mia M. ^{[7
]}

Gaziano, J. Michael ^{[8
,12
]}

Gkiokas, Georgios ^{[13
]}

Guenel, Pascal ^{[14
]}

Henderson, Brian E. ^{[5
]}

Hollenbeck, Albert ^{[15
]}

Hsing, Ann W. ^{[16
,17
,18
]}

Kolonel, Laurence N. ^{[19
]}

Isaacs, Claudine ^{[20
]}

Lubin, Jay H. ^{[1
]}

Michels, Karin B. ^{[9
,21
,23
]}

Negri, Eva ^{[24
]}

Parisi, Dominick ^{[25
]}

Petridou, Eleni Th. ^{[26
]}

Pike, Malcolm C. ^{[5
]}

Riboli, Elio ^{[27
]}

Sesso, Howard D. ^{[10
,11
,28
,29
]}

Snyder, Kirk ^{[25
]}

Swerdlow, Anthony J. ^{[6
,30
]}

Trichopoulos, Dimitrios ^{[24
]}

Ursin, Giske ^{[5
,31
,32
]}

van den Brandt, Piet A. ^{[33
]}

Van Den Eeden, Stephen K. ^{[34
]}

Weiderpass, Elisabete ^{[31
,35
,36
,37
]}

Willett, Walter C. ^{[22
]}

Ewertz, Marianne ^{[38
]}

Thomas, David B. ^{[39
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[2] Int Agcy Res Canc, Sect Environm & Radiat, F-69372 Lyon, France

[3] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON, Canada

[4] Lund Univ, Dept Oncol, Lund, Sweden

[5] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[6] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England

[7] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[8] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[9] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA

[10] Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Div Aging, Boston, MA 02115 USA

[12] VA Boston Healthcare Syst, MAVERIC, Boston, MA USA

[13] Aretaie Univ Hosp, Dept Surg, Athens, Greece

[14] Univ Paris Sud, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, Villejuif, France

[15] AARP, AARP Res, Washington, DC USA

[16] Canc Prevent Inst Calif, Fremont, CA USA

[17] Stanford Univ, Div Epidemiol, Dept Hlth Res & Policy, Palo Alto, CA 94304 USA

[18] Stanford Univ, Stanford Canc Inst, Stanford Sch Med, Stanford, CA USA

[19] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96822 USA

[20] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA

[21] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[22] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[23] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[24] Ist Richerche Farmacol, Milan, Italy

[25] IMS Inc, Rockville, MD USA

[26] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[27] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[28] Inst Canc Res, Div Prevent Med, London SW3 6JB, England

[29] Inst Canc Res, Div Aging, London SW3 6JB, England

[30] Inst Canc Res, Div Breast Canc Res, London SW3 6JB, England

[31] Canc Registry Norway, Oslo, Norway

[32] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway

[33] Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands

[34] Kaiser Permanente No Calif, Div Res, Oakland, CA USA

[35] Arctic Univ Norway, Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway

[36] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[37] Samfundet Folkhalsan, Helsinki, Finland

[38] Univ Southern Denmark, Inst Clin Res, Odense Univ Hosp, Dept Oncol, Odense, Denmark

[39] Fred Hutchinson Canc Res Ctr, Program Epidemiol, Seattle, WA 98104 USA

来源：

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE | 2014年 / 106卷 / 03期

基金：

英国医学研究理事会; 欧洲研究理事会; 美国国家卫生研究院;

关键词：

PROSTATE-CANCER; MEN; EPIDEMIOLOGY; COHORT; TESTOSTERONE; MORTALITY; CARCINOMA; EXPOSURE; DESIGN; HEALTH;

D O I：

10.1093/jnci/djt465

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The etiology of male breast cancer is poorly understood, partly because of its relative rarity. Although genetic factors are involved, less is known regarding the role of anthropometric and hormonally related risk factors. In the Male Breast Cancer Pooling Project, a consortium of 11 casecontrol and 10 cohort investigations involving 2405 case patients (n 1190 from casecontrol and n 1215 from cohort studies) and 52013 control subjects, individual participant data were harmonized and pooled. Unconditional logistic regression generated study designspecific (casecontrol/cohort) odds ratios (ORs) and 95% confidence intervals (CIs), with exposure estimates combined using fixed effects meta-analysis. All statistical tests were two-sided. Risk was statistically significantly associated with weight (highest/lowest tertile: OR 1.36; 95% CI 1.18 to 1.57), height (OR 1.18; 95% CI 1.01 to 1.38), and body mass index (BMI; OR 1.30; 95% CI 1.12 to 1.51), with evidence that recent rather than distant BMI was the strongest predictor. Klinefelter syndrome (OR 24.7; 95% CI 8.94 to 68.4) and gynecomastia (OR 9.78; 95% CI 7.52 to 12.7) were also statistically significantly associated with risk, relations that were independent of BMI. Diabetes also emerged as an independent risk factor (OR 1.19; 95% CI 1.04 to 1.37). There were also suggestive relations with cryptorchidism (OR 2.18; 95% CI 0.96 to 4.94) and orchitis (OR 1.43; 95% CI 1.02 to 1.99). Although age at onset of puberty and histories of infertility were unrelated to risk, never having had children was statistically significantly related (OR 1.29; 95% CI 1.01 to 1.66). Among individuals diagnosed at older ages, a history of fractures was statistically significantly related (OR 1.41; 95% CI 1.07 to 1.86). Consistent findings across casecontrol and cohort investigations, complemented by pooled analyses, indicated important roles for anthropometric and hormonal risk factors in the etiology of male breast cancer. Further investigation should focus on potential roles of endogenous hormones.

引用

页数：11

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