Studies Towards the Synthesis of Pristinamycin IIA

被引：1
|
作者：
Susnik, Peter [1 ]
Koert, Ulrich [1 ]
机构：
[1] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35032 Marburg, Germany
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 38期
关键词：
synthesis design; total synthesis; pristinamycin; SmI2; Barbier; streptogramins; CHROMIUM(II) CHLORIDE; (-)-VIRGINIAMYCIN M-2; ORGANIC-SYNTHESIS; REAGENTS; OXAZOLIDINONES; STREPTOGRAMINS; VIRGINIAMYCIN; GENERATION; INHIBITORS;
D O I：
10.1002/slct.202003411
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Studies towards a total synthesis of pristinamycin IIA(1) as part of group A streptogramins is described. Stereoselective syntheses of three building blocks A, B and C including the 2,3-dehydroproline substructure and their assembly into advanced CAB-precursor molecules for the natural product was achieved. Attempts to close the macrocylic ring at a late stage by Sm-2/Barbier or Nozaki-Hiyama-Takai-Kishi-reaction demonstrate challenges and limitations of this approach.
引用
收藏
页码：11797 / 11802
页数：6
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