Studies Towards the Synthesis of Pristinamycin IIA

被引：1
|
作者：
Susnik, Peter [1 ]
Koert, Ulrich [1 ]
机构：
[1] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35032 Marburg, Germany
来源：
CHEMISTRYSELECT | 2020年 / 5卷 / 38期
关键词：
synthesis design; total synthesis; pristinamycin; SmI2; Barbier; streptogramins; CHROMIUM(II) CHLORIDE; (-)-VIRGINIAMYCIN M-2; ORGANIC-SYNTHESIS; REAGENTS; OXAZOLIDINONES; STREPTOGRAMINS; VIRGINIAMYCIN; GENERATION; INHIBITORS;
D O I：
10.1002/slct.202003411
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Studies towards a total synthesis of pristinamycin IIA(1) as part of group A streptogramins is described. Stereoselective syntheses of three building blocks A, B and C including the 2,3-dehydroproline substructure and their assembly into advanced CAB-precursor molecules for the natural product was achieved. Attempts to close the macrocylic ring at a late stage by Sm-2/Barbier or Nozaki-Hiyama-Takai-Kishi-reaction demonstrate challenges and limitations of this approach.
引用
收藏
页码：11797 / 11802
页数：6
相关论文
共 50 条
  • [31] STUDIES TOWARDS A BIOMIMETIC SYNTHESIS OF THE MANZAMINES
    BALDWIN, JE
    CLARIDGE, TDW
    HEUPEL, FA
    WHITEHEAD, RC
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 339 - ORGN
  • [32] Studies towards the biomimetic synthesis of pyridomacrolidin
    Irlapati, NR
    Baldwin, JE
    Adlington, RM
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U2594 - U2595
  • [33] Studies towards the total synthesis of Hygrocins
    Rasapalli, Sivappa
    Yarrapothu, Gangadhara Rao
    Jarugumilli, Goapalakrishna
    Yu, Menglong
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [34] Studies towards the total synthesis of (-)-dictyostatin
    Pohlki, Frauke
    Panek, James S.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [35] Studies towards the Synthesis of the Antibiotic Tetrodecamycin
    He, Jing
    Baldwin, Jack E.
    Lee, Victor
    SYNLETT, 2018, 29 (08) : 1117 - 1121
  • [36] Studies towards the synthesis of aculeatin C
    Peuchmaur, Marine
    Wong, Yung-Sing
    SYNLETT, 2007, (18) : 2902 - 2906
  • [37] Studies towards the total synthesis of Phostriecin
    Kumar, Gavireddy Chaithanya
    Muralikrishna, Katta
    Satyanarayana, Vavilapalli
    Kumar, Chintakrinda Suresh
    Yadav, Jhillu Singh
    TETRAHEDRON LETTERS, 2018, 59 (05) : 454 - 456
  • [38] Studies towards the total synthesis of contignasterol
    Izzo, I
    Monica, CD
    Bifulco, G
    De Riccardis, F
    TETRAHEDRON, 2004, 60 (26) : 5577 - 5586
  • [39] Studies towards the total synthesis of (-)-callystatin A
    Yadav, J. S.
    Yadagiri, K.
    Madhuri, Ch.
    Sabitha, G.
    TETRAHEDRON LETTERS, 2011, 52 (33) : 4269 - 4272
  • [40] Studies towards the synthesis of (+)-lactacystin.
    Masse, CE
    Panek, JS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U505 - U505
12345