Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

被引：4
|
作者：
Gein, V. L. [1 ]
Kazantseva, M. I. [2 ]
Varkentin, L. I. [1 ]
Zamaraeva, T. M. [1 ]
Yankin, A. N. [3 ]
Beletskii, E. V. [4 ]
Novikova, V. V. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
[2] EA Vagner Perm State Med Univ, Perm 614990, Russia
[3] ITMO Univ, St Petersburg 197101, Russia
[4] St Petersburg State Univ, St Petersburg 199034, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 08期
关键词：
N; N-dimethyltryptamine heterocyclic analogues; pyrrolidine-2; 3-dione derivatives; antimicrobial activity; INHIBITORY-ACTIVITY; DERIVATIVES; EFFICIENT;
D O I：
10.1134/S1070363220080083
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.
引用
收藏
页码：1426 / 1431
页数：6
相关论文
共 50 条
  • [41] N-[2-(1H-Indol-3-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl]-4-methylbenzenesulfonamide
    Purushotham, Nikil
    Poojary, Boja
    MOLBANK, 2018, (03)
  • [42] 3-(4-Chlorophenyl)-1-[(E)-1-(4-chlorophenyl)-2-(4-methylphenylsulfanyl)ethenyl]-4-(4-methylphenylsulfanyl)-1H-pyrazole
    Ramesh, P.
    Manikannan, Ramaiyan
    Muthusubramanian, S.
    Sundaresan, S. S.
    Ponnuswamy, M. N.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2009, 65 : O2881 - U2020
  • [43] (Z)-3-(1H-indol-3-yl)-2-(3-thienyl)acrylonitrile and (Z)-3-[1-(4-tert-butylbenzyl)-1H-indol-3-yl]2-(3-thienyl)acrylonitrile
    Sonar, VN
    Parkin, S
    Crooks, PA
    ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2005, 61 : O78 - O80
  • [44] Synthesis and antibacterial activity of 1-(5-aryl-4-benzoyl-3-hydroxy-2- oxo-3-pyrrolin-1-yl)-2-(3-benzoylmethylene-2-oxopiperazin-1-yl)ethanes
    Gein V.L.
    Kasimova N.N.
    Panina M.A.
    Voronina É.V.
    Pharmaceutical Chemistry Journal, 2006, 40 (8) : 410 - 412
  • [45] (Z)-3-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-(3-thienyl)acrylonitrile
    Sonar, Vijayakumar N.
    Parkin, Sean
    Crooks, Peter A.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O3979 - U2372
  • [46] Synthesis and pharmacological activity of 5-aryl-4-acetyl-1-carboxyalkyl-tetrahydropyrrole-2,3-diones
    Gein V.L.
    Gein L.F.
    Porseva N.Yu.
    Shchurova I.G.
    Shurov S.N.
    Vakhrin M.I.
    Voronina É.V.
    Mardanova L.G.
    Kolla V.É.
    Pharmaceutical Chemistry Journal, 1997, 31 (5) : 251 - 254
  • [47] Ethyl 1-[3-(1H-imidazol-1-yl)propyl]-2-(4-chlorophenyl)-1H-benzo[d]imidazole-5-carboxylate dihydrate
    Yoon, Yeong Keng
    Ali, Mohamed Ashraf
    Wei, Ang Chee
    Quah, Ching Kheng
    Fun, Hoong-Kun
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2405 - U927
  • [48] Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase
    Muscia, Gisela C.
    Hautmann, Stephanie
    Buldain, Graciela Y.
    Asis, Silvia E.
    Guetschow, Michael
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (06) : 1545 - 1549
  • [49] Synthesis, reactions, and biological activity of 4(1H-indol-3-yl)-2-thioxopyridine derivatives
    Attaby, Fawzy A.
    Ramla, Mostafa M.
    Gouda, Eman M.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (03) : 517 - 528
  • [50] PIPES-ZnO NPs coupled catalyst for the synthesis of 2-((1H-indol-3-yl) (phenyl)methyl)-5,5-dimethylcyclohexane-1,3-diones
    Gadekar, Suchita S.
    Joshi, Rajesh A.
    Madje, Balaji R.
    Salunke, Shrikrishna T.
    Sapkal, Suryakant B.
    RESULTS IN CHEMISTRY, 2023, 6
12345