Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

被引：4
|
作者：
Gein, V. L. [1 ]
Kazantseva, M. I. [2 ]
Varkentin, L. I. [1 ]
Zamaraeva, T. M. [1 ]
Yankin, A. N. [3 ]
Beletskii, E. V. [4 ]
Novikova, V. V. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
[2] EA Vagner Perm State Med Univ, Perm 614990, Russia
[3] ITMO Univ, St Petersburg 197101, Russia
[4] St Petersburg State Univ, St Petersburg 199034, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 08期
关键词：
N; N-dimethyltryptamine heterocyclic analogues; pyrrolidine-2; 3-dione derivatives; antimicrobial activity; INHIBITORY-ACTIVITY; DERIVATIVES; EFFICIENT;
D O I：
10.1134/S1070363220080083
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.
引用
收藏
页码：1426 / 1431
页数：6
相关论文
共 50 条
  • [1] Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones
    V. L. Gein
    M. I. Kazantseva
    L. I. Varkentin
    T. M. Zamaraeva
    A. N. Yankin
    E. V. Beletskii
    V. V. Novikova
    Russian Journal of General Chemistry, 2020, 90 : 1426 - 1431
  • [2] Synthesis and Structure of 5-Aryl-4-[hydroxy(phenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones
    Gein, V. L.
    Varkentin, L. I.
    Kazantseva, M. I.
    Dmitriev, M. V.
    Yankin, A. N.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2019, 89 (11) : 2196 - 2200
  • [3] Synthesis and Structure of 5-Aryl-4-[hydroxy(phenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones
    V. L. Gein
    L. I. Varkentin
    M. I. Kazantseva
    M. V. Dmitriev
    A. N. Yankin
    Russian Journal of General Chemistry, 2019, 89 : 2196 - 2200
  • [4] Synthesis of 1-[2-(1H-Indol-3-yl)ethyl]-4-acetyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones
    Nasakin, O. E.
    Kazantseva, M. I.
    Varkentin, L. I.
    Gein, V. L.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (06) : 1270 - 1272
  • [5] Synthesis of 1-[2-(1H-Indol-3-yl)ethyl]-4-acetyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones
    O. E. Nasakin
    M. I. Kazantseva
    L. I. Varkentin
    V. L. Gein
    Russian Journal of General Chemistry, 2018, 88 : 1270 - 1272
  • [6] Crystal structure of 2-(4-chlorophenyl)-4-(1H-indol-3-yl)-6-phenylpyridine-3-carbonitrile
    Vishnupriya, R.
    Suresh, J.
    Gunasekaran, Pethaiah
    Perumal, Subbu
    Lakshman, P. L. Nilantha
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2014, 70 : O978 - +
  • [7] 2′-[(5-bromo-1H-indol-3-yl)methylene]-2-(1H-indol-3-yl)acetohydrazide ethyl acetate solvate
    Ali, Hapipah M.
    Shimar, Jamaludin Nazzatush
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O2731 - U1620
  • [8] Dichloridobis(2-{1-[2-(1H-indol-3-yl)-ethyliminio]ethyl}phenolate-κO)zinc(II)-2-{1-[2-(1H-indol-3-yl)ethyliminio]ethyl}-phenolate (1/2)
    Ali, Hapipah M.
    Ibrahim, Mohamed
    Mustafa, Mohamed
    Rizal, Mohd. Razali
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : M718 - U923
  • [9] 2′-[(5-chloro-1H-indol-3-yl)methylene]2-(1H-indol-3-yl)acetohydrazide
    Ali, Hapipah M.
    Shimar, Jamaludin Nazzatush
    Jefrey, Basirun Wan
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O1807 - O1808
  • [10] 2-(4-Chlorophenyl)-4-[1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl]-5-methyl-1H-pyrazol-3(2H)-one
    Rabnawaz, Muhammad
    Shah, Muhammad Raza
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O2569 - U535
12345