Synthesis and Antibacterial Activity of 5-Aryl-4-[hydroxy(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones

被引：4
|
作者：
Gein, V. L. [1 ]
Kazantseva, M. I. [2 ]
Varkentin, L. I. [1 ]
Zamaraeva, T. M. [1 ]
Yankin, A. N. [3 ]
Beletskii, E. V. [4 ]
Novikova, V. V. [1 ]
机构：
[1] Perm State Pharmaceut Acad, Perm 614990, Russia
[2] EA Vagner Perm State Med Univ, Perm 614990, Russia
[3] ITMO Univ, St Petersburg 197101, Russia
[4] St Petersburg State Univ, St Petersburg 199034, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 08期
关键词：
N; N-dimethyltryptamine heterocyclic analogues; pyrrolidine-2; 3-dione derivatives; antimicrobial activity; INHIBITORY-ACTIVITY; DERIVATIVES; EFFICIENT;
D O I：
10.1134/S1070363220080083
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of tryptamine with aromatic aldehydes and 4-chlorobenzoylpyruvic acid methyl ester led to the formation of 5-aryl-4-[hydroxy-(4-chlorophenyl)methylene]-1-[2-(1H-indol-3-yl)ethyl]pyrrolidine-2,3-diones. The resulting compounds were tested for antimicrobial activity.
引用
收藏
页码：1426 / 1431
页数：6
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