Toward pyridine-fused selenium-containing antioxidants

被引：12

作者：

Fenner, T ^{[1
]}

Schiesser, CH ^{[1
]}

机构：

[1] Univ Melbourne, Sch Chem, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3010, Australia

来源：

MOLECULES | 2004年 / 9卷 / 06期

关键词：

free radical; homolytic substitution; selenium; antioxidants;

D O I：

10.3390/90600472

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photolysis of the thiohydroximate ester derivative 21 of 2-carboethoxy-2-(2-(benzylseleno)pyridin-3-yl)tridecylcarboxylic acid (20) affords 2-dodecyl-2-carboethoxy-2,3-dihydroselenolo[2,3-b]pyridine (22) in 89% yield in a process presumably involving intramolecular homolytic substitution by a tertiary alkyl radical at selenium with loss of a benzyl radical. Work toward extending this methodology to the preparation of pyridine-fused selenium analogues of antioxidants is described.

引用

页码：472 / 479

页数：8

共 50 条

[41] Effect of selenium-containing compounds on hepatic chemoprotective enzymes in mice
El-Sayed, WM
Aboul-Fadl, T
Lamb, JG
Roberts, JC
Franklin, MR
TOXICOLOGY, 2006, 220 (2-3) : 179 - 188
[42] Selenium-Containing Organic Fertilizer Application Affects Yield, Quality, and Distribution of Selenium in Wheat
Chen, Peng
Shaghaleh, Hiba
Hamoud, Yousef Alhaj
Wang, Jing
Pei, Wenxia
Yuan, Xianfu
Liu, Jianjian
Qiao, Cece
Xia, Wenhui
Wang, Jianfei
LIFE-BASEL, 2023, 13 (09):
[43] Selenium-Containing Agents Acting on Cancer-A New Hope?
Garbo, Sabrina
Di Giacomo, Silvia
Lazewska, Dorota
Honkisz-Orzechowska, Ewelina
Di Sotto, Antonella
Fioravanti, Rossella
Zwergel, Clemens
Battistelli, Cecilia
PHARMACEUTICS, 2023, 15 (01)
[44] Morphology and Thermodynamics of Selenium-Containing Nanosystems: The Effect of Polymer Stabilizers
Valueva, S. V.
Kipper, A. I.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A, 2017, 91 (04) : 609 - 612
[45] Synthesis of Optically Active Selenium-Containing Isotryptophan, Homoisotryptophan, and Homotryptophan
Goswami, Koushik
Chakraborty, Amrita
Sinha, Surajit
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 2013 (18) : 3645 - 3647
[46] Synthesis of selenium-containing polysaccharides and evaluation of antioxidant activity in vitro
Wang, Junlong
Zhao, Baotang
Wang, Xiaofang
Yao, Jian
Zhang, Ji
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2012, 51 (05) : 987 - 991
[47] Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity
Zhao, Liwei
Li, Jianfeng
Li, Yiquan
Liu, Jianwen
Wirth, Thomas
Li, Zhong
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (08) : 2558 - 2563
[48] Selenium-containing Curcumin Polymer for Anti-liver Fibrosis
Zhu, Yifeng
Neng, Jing
He, Leilei
Tang, Huadong
ADVANCED MATERIALS AND PROCESSES, PTS 1-3, 2011, 311-313 : 1061 - +
[49] Purification and characterization of selenium-containing phycocyanin from selenium-enriched Spirulina platensis
Chen, Tianfeng
Wong, Yum-Shing
Zheng, Wenjie
PHYTOCHEMISTRY, 2006, 67 (22) : 2424 - 2430
[50] Stereoselective Synthesis of Selenium-Containing Glycoconjugates via the Mitsunobu Reaction
Serpico, Luigia
De Nisco, Mauro
Cermola, Flavio
Manfra, Michele
Pedatella, Silvana
MOLECULES, 2021, 26 (09):

← 1 2 3 4 5 →