Toward pyridine-fused selenium-containing antioxidants

被引：12
|
作者：
Fenner, T [1 ]
Schiesser, CH [1 ]
机构：
[1] Univ Melbourne, Sch Chem, Bio21 Mol Sci & Biotechnol Inst, Parkville, Vic 3010, Australia
来源：
MOLECULES | 2004年 / 9卷 / 06期
关键词：
free radical; homolytic substitution; selenium; antioxidants;
D O I：
10.3390/90600472
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Photolysis of the thiohydroximate ester derivative 21 of 2-carboethoxy-2-(2-(benzylseleno)pyridin-3-yl)tridecylcarboxylic acid (20) affords 2-dodecyl-2-carboethoxy-2,3-dihydroselenolo[2,3-b]pyridine (22) in 89% yield in a process presumably involving intramolecular homolytic substitution by a tertiary alkyl radical at selenium with loss of a benzyl radical. Work toward extending this methodology to the preparation of pyridine-fused selenium analogues of antioxidants is described.
引用
收藏
页码：472 / 479
页数：8
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