Multi-Level Regulation of Opioid-Induced Respiratory Depression

被引：34
|
作者：
Palkovic, Barbara [1 ,2 ]
Marchenko, Vitaliy [1 ]
Zuperku, Edward J. [1 ,3 ]
Stuth, Eckehard A. E. [1 ,4 ]
Stucke, Astrid G. [1 ,4 ]
机构：
[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] Univ Osijek, Fac Med, Osijek, Croatia
[3] Zablocki VA Med Ctr, Milwaukee, WI USA
[4] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA
来源：
PHYSIOLOGY | 2020年 / 35卷 / 06期
关键词：
awake drive; chemodrive; opioids; Parabrachial Nucleus/Kolliker-Fuse Complex; preBotzinger Complex; PRE-BOTZINGER COMPLEX; MIDBRAIN PERIAQUEDUCTAL GRAY; METHYL-D-ASPARTATE; IONOTROPIC GLUTAMATE RECEPTORS; MEDULLARY INSPIRATORY NEURONS; KOLLIKER-FUSE NEURONS; VENTILATORY RESPONSE; PREBOTZINGER COMPLEX; PARABRACHIAL NUCLEUS; RHYTHM GENERATION;
D O I：
10.1152/physiol.00015.2020
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBotzinger Complex as well as from depression of the Parabrachial/Kalliker-Fuse Complex, which provides excitatory drive to preBotzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.
引用
收藏
页码：391 / 404
页数：14
相关论文
共 50 条
  • [1] Opioid-induced respiratory depression
    Jansen, S. C.
    Dahan, A.
    BJA EDUCATION, 2024, 24 (03) : 100 - 106
  • [2] AVOIDING OPIOID-INDUCED RESPIRATORY DEPRESSION
    PASERO, CL
    MCCAFFERY, M
    AMERICAN JOURNAL OF NURSING, 1994, 94 (04) : 24 - 30
  • [3] Mechanisms of opioid-induced respiratory depression
    Brian A. Baldo
    Michael A. Rose
    Archives of Toxicology, 2022, 96 : 2247 - 2260
  • [4] Mechanisms of opioid-induced respiratory depression
    Baldo, Brian A.
    Rose, Michael A.
    ARCHIVES OF TOXICOLOGY, 2022, 96 (08) : 2247 - 2260
  • [5] Monitoring Opioid-Induced Respiratory Depression
    Gaines, Nicole
    AMERICAN JOURNAL OF NURSING, 2017, 117 (07) : 13 - 13
  • [6] Esketamine counters opioid-induced respiratory depression
    Jonkman, K.
    van Rijnsoever, E.
    Olofsen, E.
    Aarts, L.
    Sarton, E.
    van Velzen, M.
    Niesters, M.
    Dahan, A.
    BRITISH JOURNAL OF ANAESTHESIA, 2018, 120 (05) : 1117 - 1127
  • [7] Understanding and countering opioid-induced respiratory depression
    Bateman, Jordan T.
    Saunders, Sandy E.
    Levitt, Erica S.
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 (07) : 813 - 828
  • [8] Finding inspiration in opioid-induced respiratory depression
    Garcia, Alfredo J.
    Szujewski, Caroline C.
    JOURNAL OF PHYSIOLOGY-LONDON, 2020, 598 (01): : 3 - 3
  • [9] Opioid-induced depression in the lamprey respiratory network
    Mutolo, D.
    Bongianni, F.
    Einum, J.
    Dubuc, R.
    Pantaleo, T.
    NEUROSCIENCE, 2007, 150 (03) : 720 - 729
  • [10] OPIOID-INDUCED RESPIRATORY DEPRESSION IN THE POSTOPERATIVE PERIOD
    SANDLER, AN
    ANESTHESIOLOGY CLINICS OF NORTH AMERICA, 1989, 7 (01): : 193 - 210
12345