Multi-Level Regulation of Opioid-Induced Respiratory Depression

被引：35
|
作者：
Palkovic, Barbara [1 ,2 ]
Marchenko, Vitaliy [1 ]
Zuperku, Edward J. [1 ,3 ]
Stuth, Eckehard A. E. [1 ,4 ]
Stucke, Astrid G. [1 ,4 ]
机构：
[1] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[2] Univ Osijek, Fac Med, Osijek, Croatia
[3] Zablocki VA Med Ctr, Milwaukee, WI USA
[4] Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA
来源：
PHYSIOLOGY | 2020年 / 35卷 / 06期
关键词：
awake drive; chemodrive; opioids; Parabrachial Nucleus/Kolliker-Fuse Complex; preBotzinger Complex; PRE-BOTZINGER COMPLEX; MIDBRAIN PERIAQUEDUCTAL GRAY; METHYL-D-ASPARTATE; IONOTROPIC GLUTAMATE RECEPTORS; MEDULLARY INSPIRATORY NEURONS; KOLLIKER-FUSE NEURONS; VENTILATORY RESPONSE; PREBOTZINGER COMPLEX; PARABRACHIAL NUCLEUS; RHYTHM GENERATION;
D O I：
10.1152/physiol.00015.2020
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Opioids depress minute ventilation primarily by reducing respiratory rate. This results from direct effects on the preBotzinger Complex as well as from depression of the Parabrachial/Kalliker-Fuse Complex, which provides excitatory drive to preBotzinger Complex neurons mediating respiratory phase-switch. Opioids also depress awake drive from the forebrain and chemodrive.
引用
收藏
页码：391 / 404
页数：14
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