Stem cell fate regulation by dynein motor protein Lis1

被引：5

作者：

Will, Britta ^{[1
,2
]}

Steidl, Ulrich ^{[3
,4
]}

机构：

[1] Albert Einstein Coll Med, Dept Cell Biol, New York, NY 10461 USA

[2] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, New York, NY USA

[3] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Cell Biol,Dept Med Oncol, Ruth L & David S Gottesman Inst Stem Cell & Regen, New York, NY USA

[4] Albert Einstein Coll Med, Montefiore Med Ctr, Albert Einstein Canc Ctr, New York, NY USA

来源：

NATURE GENETICS | 2014年 / 46卷 / 03期

关键词：

DIVISION; QUIESCENCE;

D O I：

10.1038/ng.2902

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cell fate regulation is a central component of maintaining tissue homeostasis, yet the mechanisms instructing cell division diversity in tissue-specific stem cells have not been well understood. A new study uncovers a central role for microtubule motor-regulating protein Lis1 in hematopoietic stem cell fate determination and in leukemogenesis.

引用

页码：217 / 218

页数：3

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