OXYS rats as a model of senile cataract

被引：27

作者：

Kolosova, NG ^{[1
]}

Lebedev, PA

Aidagulova, SV

Morozkova, TS

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia

[2] Russian Acad Med Sci, Siberian Div, State Inst Reg Pathol & Pathomorphol, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

OXYS rats; senile cataract model; ocular lenses; biomicroscopy; ultrastructure;

D O I：

10.1023/B:BEBM.0000010967.24302.78

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Changes in the lens appear by the age of 2 months in early aging OXYS rats, at the age of 6 months these changes are detected in 100% animals, and by 12 months both eyes are involved. According to biomicroscopy findings, predominant forms of cataract are vesicular, annular, and dendritic, located in the. cortical layer and/or nucleus of the lens. Light and electron microscopy showed morphological changes involving all structural components of the lens: epithelial degeneration progressing with age, deformation of fiber architectonics, and appearance of uneven condensations. Cataract in OXYS rats corresponds to senile cataract, which makes this rat strain a unique model for studies of the pathogenesis of involutive cataract and elaboration of methods for its prevention and correction.

引用

页码：415 / 419

页数：5

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