Pharmacokinetics and Applications of Magnetic Nanoparticles

被引：2

作者：

Mao, Runyi ^{[1
]}

Wang, Jing ^{[2
]}

Pei, Jiao ^{[3
]}

Wu, Songtao ^{[1
]}

Feng, Jie ^{[1
]}

Lin, Yunfeng ^{[1
]}

Cai, Xiaoxiao ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[2] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200092, Peoples R China

[3] Sichuan Univ, West China Sch Publ Hlth, Dept Med Stat, Chengdu 610064, Sichuan Provinc, Peoples R China

来源：

CURRENT DRUG METABOLISM | 2013年 / 14卷 / 08期

基金：

中国国家自然科学基金; 国家教育部博士点专项基金资助;

关键词：

Nanomaterial; magnetic nanoparticles (MNPs); drug delivery system; hyperthermia; cancer; targeting; SUPERPARAMAGNETIC IRON-OXIDE; WHOLE-BODY HYPERTHERMIA; TEMPERATURE DISTRIBUTION; EFFICIENT DETECTION; SPHERICAL TISSUE; CANCER-TREATMENT; DRUG-DELIVERY; CELLS; CONTRAST; STABILIZATION;

D O I：

10.2174/138920021131400109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanomaterials possess enormous potential for biomedical applications, while some of the most promising nanomaterials currently under investigation demonstrate prolonged tissue retention and contain heavy metals. This article investigates the pharmacokinetics of magnetic nanoparticles (MNPs) to help identify promising candidates with optimal pharmacokinetics and clearance from the body for biomedical use and synthesize nanomaterials ideal for biomedical use. The term 'magnetic nanoparticles' (MNPs) refers to nanoparticles with ferromagnetism. Such nanoparticles have special characteristics, and many in the field of biological field have undertaken research involving, e. g., immobilized enzymes and proteins, biological cells, macromolecular separation, drug carriers, and targeted, immune, biological sensors.

引用

页码：872 / 878

页数：7

共 91 条

[1]

Alexiou C, 2000, CANCER RES, V60, P6641

[2] Targeting cancer cells: magnetic nanoparticles as drug carriers [J].

Alexiou, Christoph ;

Schmid, Roswitha J. ;

Jurgons, Roland ;

Kremer, Marcus ;

Wanner, Gerhard ;

Bergemann, Christian ;

Huenges, Ernst ;

Nawroth, Thomas ;

Arnold, Wolfgang ;

Parak, Fritz G. .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2006, 35 (05) :446-450

[3] Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia [J].

Andrä, W ;

d'Ambly, CG ;

Hergt, R ;

Hilger, I ;

Kaiser, WA .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1999, 194 (1-3) :197-203

[4] Block copolymer mediated stabilization of sub-5 nm superparamagnetic nickel nanoparticles in an aqueous medium [J].

Bala, Tanushree ;

Gunning, Robert Denis ;

Venkatesan, Munuswamy ;

Godsell, Jeffrey F. ;

Roy, Saibal ;

Ryan, Kevin M. .

NANOTECHNOLOGY, 2009, 20 (41)

[5] Brownian magnetic relaxation of water-based cobalt nanoparticle ferrofluids [J].

Bao, Y. ;

Pakhomov, A. B. ;

Krishnan, Kannan M. .

JOURNAL OF APPLIED PHYSICS, 2006, 99 (08)

[6] Cell-delivered magnetic nanoparticles caused hyperthermia-mediated increased survival in a murine pancreatic cancer model [J].

Basel, Matthew T. ;

Balivada, Sivasai ;

Wang, Hongwang ;

Shrestha, Tej B. ;

Seo, Gwi Moon ;

Pyle, Marla ;

Abayaweera, Gayani ;

Dani, Raj ;

Koper, Olga B. ;

Tamura, Masaaki ;

Chikan, Viktor ;

Bossmann, Stefan H. ;

Troyer, Deryl L. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :297-306

[7] Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent [J].

Bourrinet, P ;

Bengele, HH ;

Bonnemain, B ;

Dencausse, A ;

Idee, JM ;

Jacobs, PM ;

Lewis, JM .

INVESTIGATIVE RADIOLOGY, 2006, 41 (03) :313-324

[8] Surface spectroscopic study of the stabilization mechanism for shape-selectively synthesized nanostructured transition metal colloids [J].

Bradley, JS ;

Tesche, B ;

Busser, W ;

Masse, M ;

Reetz, RT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (19) :4631-4636

[9]

CHAN DCF, 1993, J MAGN MAGN MATER, V122, P374, DOI 10.1016/0304-8853(93)91113-L

[10] Preparation of dense spherical Ni particles and hollow NiO particles by spray pyrolysis [J].

Che, SL ;

Takada, K ;

Takashima, K ;

Sakurai, O ;

Shinozaki, K ;

Mizutani, N .

JOURNAL OF MATERIALS SCIENCE, 1999, 34 (06) :1313-1318

← 1 2 3 4 5 6 7 8 9 10 →