Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non Communicable Medical Comorbidities

被引：185

作者：

Slyepchenko, Anastasiya ^{[1
]}

Maes, Michael ^{[2
,3
,4
,5
,6
]}

Jacka, Felice N. ^{[2
,7
,8
,9
]}

Koehler, Cristiano A. ^{[10
,11
]}

Barichello, Tatiana ^{[12
]}

McIntyre, Roger S. ^{[13
]}

Berk, Michael ^{[2
,14
,15
,16
]}

Grande, Iria ^{[17
]}

Foster, Jane A. ^{[18
]}

Vieta, Eduard ^{[17
]}

Carvalho, Andre F. ^{[10
]}

机构：

[1] McMaster Univ, McMaster Integrat Neurosci Discovery & Study MiND, Hamilton, ON, Canada

[2] Deakin Univ, Sch Med & Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic, Australia

[3] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand

[4] Univ Estadual Londrina, Dept Psychiat, Fac Med, Londrina, Brazil

[5] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria

[6] Revitalis, Waalre, Netherlands

[7] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia

[8] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Melbourne, Vic, Australia

[9] Black Dog Inst, Sydney, NSW, Australia

[10] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil

[11] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil

[12] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA

[13] Univ Toronto, Univ Hlth Network, Dept Psychiat, Mood Disorder Psychopharmacol Unit, Toronto, ON, Canada

[14] Univ Melbourne, Orygen, Natl Ctr Excellence Youth Mental Hlth, Dept Psychiat, Parkville, Vic, Australia

[15] Univ Melbourne, Ctr Youth Mental Hlth, Dept Psychiat, Parkville, Vic, Australia

[16] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[17] Univ Barcelona, CIBERSAM, IDIBAPS, Bipolar Disorder Unit,Inst Neurosci,Hosp Clin, Barcelona, Spain

[18] McMaster Univ, Brain Body Inst, St Josephs Healthcare, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

来源：

PSYCHOTHERAPY AND PSYCHOSOMATICS | 2017年 / 86卷 / 01期

基金：

英国医学研究理事会;

关键词：

Mood disorders; Obesity; Depression; Diabetes; Microbiota; Chronic fatigue syndrome; Inflammation; Psychiatry; Irritable bowel syndrome; Oxidative stress; IRRITABLE-BOWEL-SYNDROME; CHRONIC-FATIGUE-SYNDROME; GRAM-NEGATIVE ENTEROBACTERIA; MESENTERIC LYMPH-NODES; C-REACTIVE PROTEIN; NITROSATIVE STRESS; OXIDATIVE STRESS; ADIPOSE-TISSUE; IMMUNE-SYSTEM; METABOLIC SYNDROME;

D O I：

10.1159/000448957

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut -brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE database up until May 1, 2016 for studies which investigated intestinal dysbiosis and bacterial translocation (the 'leaky gut') in the pathophysiology of MDD and co-occurring somatic comorbidities with an emphasis on IBS, CFS, obesity, and T2DM. Results: The composition of the gut microbiota is influenced by several genetic and environmental factors (e.g. diet). Several lines of evidence indicate that gut-microbiotadiet interactions play a significant pathophysiological role in MDD and related medical comorbidities. Gut dysbiosis and the leaky gut may influence several pathways implicated in the biology of MDD, including but not limited to immune activation, O&NS, and neuroplasticity cascades. However, methodological inconsistencies and limitations limit comparisons across studies. Conclusions: Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives. (C) 2016 S. Karger AG, Basel

引用

页码：31 / 46

页数：16

共 204 条

[91] Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression [J].