Interplay between exchange protein directly activated by cAMP (Epac) and microtubule cytoskeleton

被引：48

作者：

Mei, Fang C. ^{[1
]}

Cheng, Xiaodong ^{[1
]}

机构：

[1] Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA

来源：

MOLECULAR BIOSYSTEMS | 2005年 / 1卷 / 04期

关键词：

D O I：

10.1039/b511267b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exchange protein directly activated by cAMP (Epac) is a newly discovered cAMP receptor that mediates the intracellular cAMP actions in addition to the classic cAMP-dependent protein kinase system, In this study, we show that Epac interacts directly with tubulin, co-purifies with cellular microtubules, and co-localizes with the mitotic spindle assembly. Association with microtubules suppresses Epac-mediated Rapl activation, while the binding of Epac promotes microtubule formation. These results demonstrate that Epac plays an important role in connecting the microtubule cytoskeleton network and intracellular cAMP-signalling.

引用

页码：325 / 331

页数：7

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