Improving rotavirus vaccine coverage: Can newer-generation and locally produced vaccines help?

被引:22
|
作者
Deen, Jacqueline [1 ]
Lopez, Anna Lena [1 ]
Kanungo, Suman [2 ]
Wang, Xuan-Yi [3 ,4 ,5 ]
Dang Duc Anh [6 ]
Tapia, Milagritos [7 ]
Grais, Rebecca F. [8 ]
机构
[1] Univ Philippines, Natl Inst Hlth, Inst Child Hlth & Human Dev, Manila, Philippines
[2] ICMR, Natl Inst Cholera & Enter Dis, Div Epidemiol, Kolkata, W Bengal, India
[3] Fudan Univ, MoE, Key Lab Med Mol Virol, Shanghai, Peoples R China
[4] Fudan Univ, MoH, Shanghai, Peoples R China
[5] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
[6] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam
[7] Univ Sch Med, Ctr Vaccine Dev, Baltimore, MD USA
[8] Epicentre, Dept Res, Paris, France
关键词
Rotavirus; rotavirus vaccine; rotavirus vaccination; DOUBLE-BLIND; INFECTION; CHILDREN; EFFICACY; IMMUNOGENICITY; INFANTS; AFRICAN; IMPACT; SAFETY; TRIAL;
D O I
10.1080/21645515.2017.1403705
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
There are two internationally available WHO-prequalified oral rotavirus vaccines (Rotarix and RotaTeq), two rotavirus vaccines licensed in India (Rotavac and Rotasiil), one in China (Lanzhou lamb rotavirus vaccine) and one in Vietnam (Rotavin-M1), and several candidates in development. Rotavirus vaccination has been rolled out in Latin American countries and is beginning to be deployed in sub-Saharan African countries but middle- and low-income Asian countries have lagged behind in rotavirus vaccine introduction. We provide a mini-review of the leading newer-generation rotavirus vaccines and compare them with Rotarix and RotaTeq. We discuss how the development and future availability of newer-generation rotavirus vaccines that address the programmatic needs of poorer countries may help scale-up rotavirus vaccination where it is needed.
引用
收藏
页码:495 / 499
页数:5
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