Diabetes and Autoimmune Diseases: Prevalence of Celiac Disease in Children and Adolescents with Type 1 Diabetes

被引：14

作者：

Mont-Serrat, Camila ^{[1
]}

Hoineff, Claudio ^{[1
]}

Meirelles, Ricardo M. R. ^{[1
]}

Kupfer, Rosane ^{[1
]}

机构：

[1] Inst Estadual Diabet Endocrinol Luiz Capriglione, Dept Diabet, Rio De Janeiro, Brazil

来源：

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2008年 / 52卷 / 09期

关键词：

Prevalence; Autoimmune disorders; Type 1 diabetes mellitus; Celiac disease;

D O I：

10.1590/S0004-27302008000900009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: Determinate the prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus (DM1) in attendance in Instituto Estadual de Diabetes a Endocrinologia Luiz Capriglione (IEDE). Methods: Blood samples were analyzed in 120 children and adolescents with DM1 from IEDE Diabetes Clinic for the IgA antitissue-transglutaminase antibody and dosage of the seric IgA. Those with positive serology were guided for upper endoscopy with small-bowel biopsy to confirm the celiac disease. Results: The antibody was positive in 3 of the 120 patients. The small-bowel biopsy was confirmatory in all of the positive patients, leading to a prevalence of celiac disease of 2.5% in the studied group. Conclusions: The prevalence of celiac disease is increased in children and adolescents with DM1 when compared with normality. As most are asymptomatic, it is recommended periodical screening of celiac disease in children with DM1. (Arq Bras Endocrinol Metab 2008; 52/9:1461-1465)

引用

页码：1461 / 1465

页数：5

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