Sugammadex: a selective relaxant binding agent for reversal of neuromuscular block

被引：11
|
作者：
Hogg, Rosemary M. G. [1 ,2 ]
Mirakhur, Rajinder K. [1 ,2 ]
机构：
[1] Queens Univ Belfast, Dept Anaesthet, Belfast BT12 6BJ, Antrim, North Ireland
[2] Queens Univ Belfast, ICM, Belfast BT12 6BJ, Antrim, North Ireland
来源：
EXPERT REVIEW OF NEUROTHERAPEUTICS | 2009年 / 9卷 / 05期
关键词：
anticholinesterase; cyclodextrin; neostigmine; neuromuscular block; sugammadex; ROCURONIUM BROMIDE; RESIDUAL PARALYSIS; PHASE-II; CYCLODEXTRINS; MULTICENTER; VECURONIUM; SINGLE; SAFETY; ORG-25969; DRUG;
D O I：
10.1586/ERN.09.22
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Neostigmine, the currently used agent for reversal of neuromuscular block, has several drawbacks, such as a slow onset of peak effect, inability to reverse deep block and the occurrence of widespread muscarinic effects. Sugammadex is a new class of reversal agent that acts by encapsulating the molecules of the relaxants rocuronium and vecuronium, for which it is a specific antagonist. Clinical trials in over 2000 subjects have shown it to be effective for reversal of block by these two relaxants even from deep levels, in doses of 2.0-4.0 mg/kg. Sugammadex can also reverse an intense (profound) high-dose rocuronium block, but the dose required in this situation is 16.0 mg/kg. The agent has been found to be safe so far, with few side effects.
引用
收藏
页码：599 / 608
页数：10
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