New Humulenes from Hyptis incana (Labiatae)

被引：0

作者：

Satoh, Mitsuru ^{[1
]}

Satoh, Yoshio ^{[2
]}

Anzai, Yasuhiro ^{[1
]}

Ajisawa, Daisuke ^{[1
]}

Matsuzaki, Keiichi ^{[3
]}

Makino, Mitsuko ^{[3
]}

Fujimoto, Yasuo ^{[4
]}

机构：

[1] Showa Pharmaceut Univ, Lab Drug Design & Med Chem, Machida, Tokyo 1948543, Japan

[2] Showa Pharmaceut Univ, Dept Clin & Biomed Sci, Machida, Tokyo 1948543, Japan

[3] Nihon Univ, Sch Pharm, Funabashi, Chiba 2748555, Japan

[4] Nihon Univ, Coll Humanities & Sci, Dept Gen Studies, Setagaya Ku, Tokyo 1568550, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2013年 / 8卷 / 12期

关键词：

Hyptis incana; Labiatae; Humulene-type sesquiterpene; Cytotoxicity; Leukemia cell; CONSTITUENTS; DITERPENES; OFFICINALIS; PLANTS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new humulene-type sesquiterpenes, named hyptishumulene I (1) and II (2), have been isolated, together with eight known compounds, a humulene-type sesquiterpene (3), a monoterpene (4) and six abietane-type diterpenoids (5-10) from the aerial parts of Hyptis incana (Labiatae). The cytotoxic activity of the isolated compounds against mouse leukemia cells (L1210) was examined. The abietane-type diterpenoids (5-10) showed rather potent growth inhibitory activity (IC50<15 mu M), while the new humulene-type compounds (1 and 2) exhibited moderate activity (IC50>50 mu M).

引用

页码：1665 / 1668

页数：4

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