Grayanoids from the Ericaceae family: structures, biological activities and mechanism of action

被引：95

作者：

Li, Yong ^{[1
,2
]}

Liu, Yun-Bao ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY REVIEWS | 2013年 / 12卷 / 02期

关键词：

Grayanoid; Diterpenoid; Structure; Bioactivity; GRAYANANE DITERPENOIDS; MOLECULAR-STRUCTURE; PIERIS-JAPONICA; SODIUM-CHANNEL; RHODODENDRON-JAPONICUM; GRAYANOTOXIN-VII; MINOR DITERPENE; POINT-MUTATIONS; MAD HONEY; D-RING;

D O I：

10.1007/s11101-013-9299-z

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Grayanoids, occurring exclusively in Ericaceae plants, are well-known highly toxic components from the genera Rhododendron, Pieris, Leucothoe, Craibiodendron, Lyonia, Kalmia, etc. Grayanoids have been the topic of research in many phytochemical and pharmacological laboratories due to their complex structures and fascinating bioactivities. This review, citing 100 references, summarises their chemistry, including the total synthesis and bioactivity of grayanoids isolated from the Ericaceae family in the last five decades, to illustrate the chemo-diversity and biological significance of these diterpenoids.

引用

页码：305 / 325

页数：21

共 99 条

[1]

Bao GH, 2003, PLANTA MED, V69, P434, DOI 10.1055/s-2003-39716

[2]

Bao GH, 2002, CHINESE CHEM LETT, V13, P955

[3] Studies directed to the synthesis of the unusual cardiotoxic agent kalmanol. Enantioselective construction of the advanced tetracyclic 7-oxy-5,6-dideoxy congener [J].