Toward theranostic nanoparticles: CB[7]-functionalized iron oxide for drug delivery and MRI

被引：31

作者：

Benyettou, Farah ^{[1
]}

Milosevic, Irena ^{[2
]}

Lalatonne, Yoann ^{[2
]}

Warmont, Fabienne ^{[3
]}

Assah, Rana ^{[1
]}

Olsen, John-Carl ^{[4
]}

Jouaid, Mustapha ^{[5
]}

Motte, Laurence ^{[2
]}

Platas-Iglesias, Carlos ^{[6
]}

Trabolsi, Ali ^{[1
]}

机构：

[1] New York Univ Abu Dhabi, Ctr Sci & Engn, Abu Dhabi, U Arab Emirates

[2] Univ Paris 13, Sorbonne Paris Cite, CNRS, Lab CSPBAT,UMR 7244, F-93017 Bobigny, France

[3] Univ Orlean, CNRS, CRMD, F-45071 Orleans, France

[4] Indiana Univ Kokomo, Sch Sci, Kokomo, IN 46904 USA

[5] Masdar Inst Sci & Technol, Nano labs Div, Abu Dhabi, U Arab Emirates

[6] Univ A Coruna, Dept Quim Fundamental, La Coruna 15008, Spain

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 38期

关键词：

MAGNETIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; CUCURBITURIL HOMOLOGS; COMPLEXES; ASSEMBLIES; MAGHEMITE; CANCER;

D O I：

10.1039/c3tb20852d

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Iron oxide (gamma-Fe2O3) nanoparticles (NPs) were efficiently coated with the water soluble macrocycle cucurbit [7]uril (CB[7]) by microwave heating. Density functional theory (DFT) calculations support a binding model in which the carbonyl oxygens of CB[7] coordinate directly to surface Fe3+ ions. The modified particles (CB [7] NPs) are stable under a wide pH range (2-12) and have a transverse relaxivity, R-2, of 113 s(-1) mM(-1). Nile red (NR) dye was loaded into the cavities of the surface-adsorbed CB[7]s, and intracellular delivery of the dye to HCT116 cells was observed by confocal laser scanning microscopy. The dye-loaded particles (CB[7] NPs superset of NR) have a R-2 of 172 s(-1) mM(-1). The stability, biocompatibility, and dual purpose functionality (drug delivery and magnetic resonance imaging) of the CB[7] NPs herald the theranostic potential of this system.

引用

页码：5076 / 5082

页数：7

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