An Air-Stable Copper Reagent for Nucleophilic Trifluoromethylthiolation of Aryl Halides

被引：270

作者：

Weng, Zhiqiang ^{[1
,2
]}

He, Weiming ^{[1
,2
]}

Chen, Chaohuang ^{[1
,2
]}

Lee, Richmond ^{[3
]}

Tan, Davin ^{[3
]}

Lai, Zhiping ^{[3
]}

Kong, Dedao ^{[1
,2
]}

Yuan, Yaofeng ^{[1
,2
]}

Huang, Kuo-Wei ^{[3
]}

机构：

[1] Fuzhou Univ, Dept Chem, Fuzhou 350002, Peoples R China

[2] Fuzhou Univ, Fujian Prov Key Lab Photocatalysis, State Key Lab Breeding Base, Fuzhou 350002, Peoples R China

[3] KAUST, Div Phys Sci & Engn, Thuwal 239556900, Saudi Arabia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 05期

基金：

中国国家自然科学基金;

关键词：

copper; cross-coupling; C?S bonds; trifluoromethylthiolation; ALPHA-FLUORINATED ETHERS; CATALYZED TRIFLUOROMETHYLATION; BORONIC ACIDS; BOND FORMATION; OXIDATIVE TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; CONVENIENT SYNTHESIS; ROOM-TEMPERATURE; TERMINAL ALKYNES; SULFIDES;

D O I：

10.1002/anie.201208432

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF 3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1548 / 1552

页数：5

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