The effects of derivatives of pantothenic acid on free-radical processes and the corticosterone level in the hippocampus and neocortex of rats after interoceptive stress

被引：2

作者：

Stepanichev, M. Yu ^{[1
]}

Onufriev, M. V. ^{[1
]}

Piskunov, A. K. ^{[1
]}

Moiseeva, Yu V. ^{[1
]}

Lazareva, N. A. ^{[1
]}

Moiseenok, A. G. ^{[2
]}

Gusev, P. V. ^{[1
]}

Gulyaeva, N. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia

[2] Natl Acad Sci, Inst Pharmacol & Biochem, Sci Prod Ctr, Grodno, BELARUS

来源：

NEUROCHEMICAL JOURNAL | 2013年 / 7卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

hippocampus; interoceptive stress; calcium hopanthenate; panthenol; lipopolysaccharide; APICAL DENDRITES; ACTIVATION; EXPOSURE; NEURONS; ATROPHY; HYPOTHALAMUS; DEFICITS; ASSAY; BETA;

D O I：

10.1134/S1819712413020062

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study, the effects of interoceptive stress on the indices of free-radical oxidation and the corticosterone contents in the brain and blood of male rats were examined. In addition, we studied the effects of the GABA-like nootropic drug calcium hopanthenate and panthenol on these indices after stress. Interoceptive stress was induced by intraperitoneal injection of bacterial lipopolysaccharide and the studies were performed 24 h after injection. The derivatives of pantothenic acid substantially attenuated corticosterone accumulation in the hippocampus after interoceptive stress induced by systemic immune challenge but did not prevent a stress-induced increase in the level of substances that reacted with thiobarbituric acid in the blood of the animals.

引用

页码：144 / 149

页数：6

共 14 条

[1] The effects of derivatives of pantothenic acid on free-radical processes and the corticosterone level in the hippocampus and neocortex of rats after interoceptive stress
M. Yu. Stepanichev
M. V. Onufriev
A. K. Piskunov
Yu. V. Moiseeva
N. A. Lazareva
A. G. Moiseenok
P. V. Gusev
N. V. Gulyaeva
Neurochemical Journal, 2013, 7 : 144 - 149
[2] The Effects of Cortexin on Free-Radical Oxidation and Inflammatory Processes in Rats with Normal and Accelerated Aging
Stepanichev, M. Yu.
Onufriev, M. V.
Peregud, D. I.
Lazareva, N. A.
Moiseeva, Yu. V.
Nesterenko, A. N.
Novikova, M. R.
Stefanova, N. A.
Kolosova, N. G.
Gulyaeva, N. V.
NEUROCHEMICAL JOURNAL, 2018, 12 (02) : 184 - 194
[3] The Effects of Cortexin on Free-Radical Oxidation and Inflammatory Processes in Rats with Normal and Accelerated Aging
M. Yu. Stepanichev
M. V. Onufriev
D. I. Peregud
N. A. Lazareva
Yu. V. Moiseeva
A. N. Nesterenko
M. R. Novikova
N. A. Stefanova
N. G. Kolosova
N. V. Gulyaeva
Neurochemical Journal, 2018, 12 : 184 - 194
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Ayaz, Lokman
Emre, Mustafa
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ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (07) : 5677 - 5684
[5] Effects of Acute Hypoxia on the Intensity of Free-Radical Processes in the Basal Nuclei of the Brain and Behavior in Rats in the Open Field Test in Conditions of an Altered Photoperiod
I. Yu. Sopova
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Neuroscience and Behavioral Physiology, 2012, 42 (8) : 806 - 811
[6] EFFECTS OF HIS-PHE-ARG-TRP-PRO-GLY-PRO PEPTIDE ON FREE-RADICAL OXIDATION PROCESSES IN CONDITIONS OF CHRONIC RESTRAINT STRESS
Vorvul, A. O.
Bobyntsev, I. I.
Medvedeva, O. A.
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BULLETIN OF RUSSIAN STATE MEDICAL UNIVERSITY, 2021, (06): : 61 - 66
[7] LONG-CHAIN-SUBSTITUTED URIC-ACID AND 5,6-DIAMINOURACIL DERIVATIVES AS NOVEL AGENTS AGAINST FREE-RADICAL PROCESSES - SYNTHESIS AND INVITRO ACTIVITY
FRAISSE, L
VERLHAC, JB
ROCHE, B
RASCLE, MC
RABION, A
SERIS, JL
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (10) : 1465 - 1473
[8] Effects of chronic noise stress on spatial memory of rats in relation to neuronal dendritic alteration and free radical-imbalance in hippocampus and medial prefrontal cortex
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NEUROSCIENCE LETTERS, 2006, 399 (1-2) : 17 - 22
[9] LUNG VASCULAR AND AIRWAY EFFECTS IN RATS OF 8-EPI-PGF2-ALPHA, A NONCYCLOOXYGENASE FREE-RADICAL CATALYZED PRODUCT OF ARACHIDONIC-ACID
BANERJEE, M
KANG, K
MORROW, J
ROBERTS, L
NEWMAN, J
FASEB JOURNAL, 1991, 5 (06): : A1722 - A1722
[10] SYSTEMIC EFFECTS OF NEW MODIFIED SUTURE THREADS ON FREE RADICAL PROCESSES IN RATS' BLOOD UNDER SURGICAL TRAUMA IN CONDITIONS OF CHRONIC PSYCHO-EMOTIONAL STRESS
Skotnikova, L. V.
Kostenko, V. A.
WORLD OF MEDICINE AND BIOLOGY, 2011, 29 (02): : 39 - 43

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