An outbreak of Burkholderia multivorans beyond cystic fibrosis patients

被引:19
作者
Hanulik, V. [1 ]
Webber, M. A. [2 ]
Chroma, M. [1 ,3 ]
Uvizl, R. [4 ]
Holy, O. [5 ]
Whitehead, R. N. [2 ]
Baugh, S. [2 ]
Matouskova, I. [5 ]
Kolar, M. [1 ]
机构
[1] Palacky Univ, Dept Microbiol, Fac Med & Dent, CR-77147 Olomouc, Czech Republic
[2] Univ Birmingham, Sch Immun & Infect, Antimicrobial Agents Res Grp, Birmingham B15 2TT, W Midlands, England
[3] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, CR-77147 Olomouc, Czech Republic
[4] Univ Hosp Olomouc, Dept Anaesthesiol & Intens Care Med, Olomouc, Czech Republic
[5] Palacky Univ, Dept Prevent Med, Fac Med & Dent, CR-77147 Olomouc, Czech Republic
关键词
Chlorhexidine; Hospital-acquired pneumonia; Intensive care unit; Resistance; EPIDEMIOLOGY;
D O I
10.1016/j.jhin.2013.04.001
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Strains of the Burkholderia cepacia complex (Bcc) are opportunistic pathogens capable of causing serious infection in cystic fibrosis patients. Recently we identified a suspected outbreak of infection with Bcc strains at the University Hospital Olomouc. Seventy-four Bcc strains were isolated from 52 patients, most of whom (N = 48) did not suffer from cystic fibrosis. Most frequently (N = 46) Burkholderia multivorans was isolated and 24 (52.2%) of these strains were clonal. Fifteen of these strains were isolated from intensive care patients, five of whom died from hospital-acquired pneumonia. B. multivorans can cause serious outbreaks of infection beyond cystic fibrosis sufferers. (C) 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:248 / 251
页数:4
相关论文
共 8 条
[1]   Determination of minimum inhibitory concentrations [J].
Andrews, JM .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 :5-16
[2]   Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing [J].
Baldwin, Adam ;
Mahenthiralingam, Eshwar ;
Drevinek, Pavel ;
Pope, Chris ;
Waine, David J. ;
Henry, Deborah A. ;
Speert, David P. ;
Carter, Phil ;
Vandamme, Peter ;
LiPuma, John J. ;
Dowson, Chris G. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (01) :290-295
[3]   mlstdbNet - distributed multi-locus sequence typing (MLST) databases [J].
Jolley, KA ;
Chan, MS ;
Maiden, MCJ .
BMC BIOINFORMATICS, 2004, 5 (1)
[4]   DNA-based diagnostic approaches for identification of Burkholderia cepacia complex, Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, and Burkholderia cepacia genomovars I and III [J].
Mahenthiralingam, E ;
Bischof, J ;
Byrne, SK ;
Radomski, C ;
Davies, JE ;
Av-Gay, Y ;
Vandamme, P .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (09) :3165-3173
[5]   Epidemiology of Burkholderia cepacia infection in patients with cystic fibrosis: Analysis by randomly amplified polymorphic DNA fingerprinting [J].
Mahenthiralingam, E ;
Campbell, ME ;
Henry, DA ;
Speert, DP .
JOURNAL OF CLINICAL MICROBIOLOGY, 1996, 34 (12) :2914-2920
[6]   "Cepacia Syndrome" Associated With Burkholderia cepacia (Genomovar I) Infection in an Adolescent With Cystic Fibrosis [J].
Nash, Edward F. ;
Thomas, Ajit ;
Whitmill, Richard ;
Rashid, Rifat ;
Barker, Bethan ;
Whitehouse, Joanna L. ;
Honeybourne, David ;
Rayner, Rosie J. .
PEDIATRIC PULMONOLOGY, 2011, 46 (05) :512-514
[7]   Biocide susceptibility of the Burkholderia cepacia complex [J].
Rose, Helen ;
Baldwin, Adam ;
Dowson, Christopher G. ;
Mahenthiralingam, Eshwar .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 63 (03) :502-510
[8]   HOSPITAL-ACQUIRED PNEUMONIA IN ICU PATIENTS [J].
Uvizl, Radovan ;
Hanulik, Vojtech ;
Husickova, Vendula ;
Sedlakova, Miroslava Htoutou ;
Adamus, Milan ;
Kolar, Milan .
BIOMEDICAL PAPERS-OLOMOUC, 2011, 155 (04) :373-378