TP53 gene and p53 protein vs. endometrial carcinoma

被引：2

作者：

Zajac, Agnieszka ^{[1
]}

Stachowiak, Grzegorz ^{[1
]}

Stetkiewicz, Tomasz ^{[1
]}

Wilczynski, Jacek R. ^{[1
]}

机构：

[1] Inst Ctr Zdrowia Matki Polki Lodzi, Klin Ginekol & Onkol Ginekol, Lodz, Poland

来源：

MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY | 2013年 / 12卷 / 03期

关键词：

endometrial carcinoma; TP53; p53; menopause;

D O I：

10.5114/pm.2013.36588

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The TP53 gene and its protein p53 play an important role in the cell cycle, DNA repair and apoptosis initiation. Genetic anomalies of TP53 are related to some neoplasms, including endometrial cancer. These alterations may initiate cancerogenesis within endometrium, being observed in type II and poorly-differentiated carcinomas. Immunoexpression of TP53/p53 may be helpful in the diagnostic and therapeutic process and be a prognostic factor for this carcinoma.

引用

页码：228 / 230

页数：3

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