Hemorrhagic Fever-Causing Arenaviruses: Lethal Pathogens and Potent Immune Suppressors

被引：56

作者：

Brisse, Morgan E. ^{[1
,2
]}

Ly, Hinh ^{[2
]}

机构：

[1] Univ Minnesota, Biochem Mol Biol & Biophys Grad Program, St Paul, MN 55108 USA

[2] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN 55108 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

arenaviruses; Lassa fever; host-virus interactions; innate and adaptive immunity; viral immunology; viral pathogenesis; host defense; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; STABLE SIGNAL PEPTIDE; INCLUSION-BODY DISEASE; HUMAN DENDRITIC CELLS; RNA-BINDING-PROTEIN; DEFECTIVE INTERFERING PARTICLES; IMPORTED LASSA FEVER; NEW-WORLD ARENAVIRUS; JUNIN VIRUS; RIG-I;

D O I：

10.3389/fimmu.2019.00372

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hemorrhagic fevers (HF) resulting from pathogenic arenaviral infections have traditionally been neglected as tropical diseases primarily affecting African and South American regions. There are currently no FDA-approved vaccines for arenaviruses, and treatments have been limited to supportive therapy and use of non-specific nucleoside analogs, such as Ribavirin. Outbreaks of arenaviral infections have been limited to certain geographic areas that are endemic but known cases of exportation of arenaviruses from endemic regions and socioeconomic challenges for local control of rodent reservoirs raise serious concerns about the potential for larger outbreaks in the future. This review synthesizes current knowledge about arenaviral evolution, ecology, transmission patterns, life cycle, modulation of host immunity, disease pathogenesis, as well as discusses recent development of preventative and therapeutic pursuits against this group of deadly viral pathogens.

引用

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