Gold-chlorophyll a-hybrid nanoparticles and chlorophyll a/cetyltrimethylammonium chloride self-assembled-suprastructures as novel carriers for chlorophyll a delivery in water medium: Photoactivity and photostability

被引：19

作者：

Rizzi, Vito ^{[1
]}

Vurro, Davide ^{[1
]}

Placido, Tiziana ^{[1
]}

Fini, Paola ^{[2
]}

Petrella, Andrea ^{[3
]}

Semeraro, Paola ^{[1
,2
]}

Cosma, Pinalysa ^{[1
,2
]}

机构：

[1] Univ Aldo Moro Bari, Dip Chim, Via Orabona 4, I-70126 Bari, Italy

[2] UOS Bari, CNR, IPCF, Via Orabona 4, I-70126 Bari, Italy

[3] Politecn Bari, Dipartimento Ingn Civile Ambientale Terr Edile &, Via E Orabona 4, I-70125 Bari, Italy

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2018年 / 161卷

关键词：

Chlorophyll a; Gold nanoparticles; PDT; APDT; ROS; PHOTODYNAMIC THERAPY; AQUEOUS-SOLUTIONS; CANCER; 4-THIOTHYMIDINE; AGGREGATION; DERIVATIVES; PHOTONICS; AGENTS; CHARGE;

D O I：

10.1016/j.colsurfb.2017.11.009

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The stability of Chlorophyll a in water during prolonged exposure, at room temperature, to a neon lamp has been investigated by means of UV-vis and fluorescence spectroscopies. In addition, the Chlorophyll a (photo)stability evaluation in presence of suitable carriers has been performed in order to investigate its reactivity under the same conditions, for possible and future applications in Antimicrobial Photodynamic Therapy. Cetyltrimethylammonium chloride was chosen to solubilize Chlorophyll a in water. While, cetyltrimethylammonium chloride-capped gold nanoparticles offer a great opportunity because combine the Chlorophyll a action, used as a photosensitizer in Antimicrobial Photodynamic Therapy, with gold nanoparticles effect used in photothermal therapy. Indeed, the latter ones have exhibited an interesting rise of temperature if irradiated with visible light. Overall, both examined systems, cetyltrimethylammonium chloride/Chlorophyll a and gold nanoparticles/Chlorophyll a, were able to induce the Reactive Oxygen Species formation fundamental for a potential application in Antimicrobial Photodynamic Therapy. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：555 / 562

页数：8

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