Nephrogenic Systemic Fibrosis Associated With Gadoversetamide Exposure: Treatment With Sodium Thiosulfate

被引:30
作者
Kadiyala, Deepak
Roer, David A.
Perazella, Mark A. [1 ]
机构
[1] Yale Univ, Sch Med, Dept Med, Nephrol Sect, New Haven, CT 06520 USA
关键词
Nephrogenic systemic fibrosis; gadolinium; gadoversetamide; gadodiamide; sodium thiosulfate; kidney disease; EXTRACORPOREAL PHOTOPHERESIS; DERMOPATHY; GADOLINIUM; CONTRAST; DISEASE; CELLS;
D O I
10.1053/j.ajkd.2008.09.016
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Nephrogenic systemic fibrosis (NSF) is a debilitating fibrosing disorder of patients with kidney disease that is associated with gadolinium-based contrast exposure. Most cases are linked to gadodiamide. Gadoversetamide, an agent with chelate characteristics similar to gadodiamide, has rarely been described to cause NSF With the exception of normalization of kidney function, there are no consistently effective therapies for patients with NSF. We describe 3 cases of NSF in patients with end-stage renal disease after gadolinium-based contrast exposure. Two patients received gadoversetamide and the third received gadodiamide. All 3 patients were treated early in their disease course with intravenous sodium thiosulfate and responded with improved skin changes and joint mobility. Am J Kidney Dis 53:133-137. (C) 2008 by the National Kidney Foundation, Inc.
引用
收藏
页码:133 / 137
页数:5
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