Steroidal saponins from the rhizomes of Polygonatum sibiricum

被引：59

作者：

Ahn, MJ

Kim, CY

Yoon, KD

Ryu, MY

Cheong, JH

Chin, YW

Kim, J ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2006年 / 69卷 / 03期

关键词：

D O I：

10.1021/np050394d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new steroidal saponins, named neosibiricosides A-D (1-4), were isolated from the rhizomes of Polygonatum sibiricum, along with two known spirostanol glycosides. The structures of the new glycosides were elucidated by spectroscopic methods and acid hydrolysis as (23S,24R,25R)-1-O-acetylspirost-5-ene-1 beta,3 beta,23,24-tetrol 3-O-beta-D-glucopyranosyl-(1 -> 2)-fi-D-glucopyranosyl-(1 -> 4)-beta-D-fucopyranoside (1), (25S)-1-O-acetylspirost-5-ene-1 beta,3 beta-diol 3-beta-D-glucopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranoside (2), (25S)spirost-5-en-3 beta-ol 3-O-beta-D-glucopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucopyranosyl-(1 -> 4)-2-O-acetylfi-D-galactopyranoside (3), and (25R,S)-spirost-5-en-3 beta-of 3-O-beta-D-glucopyranosyl-(1 -> 2)-beta-D-glucopyranosyl-(1 -> 4)fi-D-galactopyranoside (4). The cytotoxic activity of the isolated compounds was evaluated with human MCF-7 breast cancer cells.

引用

页码：360 / 364

页数：5

共 19 条

[1] 25R/25S stereochemistry of spirostane-type steroidal sapogenins and steroidal saponins via chemical shift of geminal protons of ring-F [J].