Taking high-speed railway prestressed concrete continuous beam bridge as research object, deflection control of bridge and the key bridge design technologies are studied. The FE method is used to calculate and analyze the static characteristics of the continuous beam bridges. The main design loads of the main include weight, temperature gradient, the settlement of bearing, the second-phase loads (uniformly distributed load) and moving loads. The influence of these loads on the bridge deflection is studied. The results show that the weight, temperature, bearing settlement, moving load influence the bridge deflection greatly. However, in these factors, the uneven settlement of bearings is the main factor.