In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth

被引：35

作者：

Gomez-Lopez, Nardhy ^{[1
,2
,3
,4
]}

Romero, Roberto ^{[1
,2
,5
,6
,7
]}

Arenas-Hernandez, Marcia ^{[1
,2
,3
,8
]}

Ahn, Hyunyoung ^{[1
,2
,3
]}

Panaitescu, Bogdan ^{[1
,2
,3
]}

Vadillo-Ortega, Felipe ^{[9
]}

Sanchez-Torres, Carmen ^{[8
]}

Salisbury, Katherine S. ^{[3
]}

Hassan, Sonia S. ^{[1
,2
,3
]}

机构：

[1] NICHD, Perinatol Res Branch, NIH, DHHS, Bethesda, MD 20892 USA

[2] NICHD, Perinatol Res Branch, NIH, DHHS, Detroit, MI USA

[3] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA

[4] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA

[5] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA

[6] Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA

[7] Wayne State Univ, Ctr Mol Obstet & Genet, Detroit, MI USA

[8] CINVESTAV, Dept Mol Biomed, Mexico City, DF, Mexico

[9] Univ Nacl Autonoma Mexico, Fac Med, Unit Vinculat, Inst Nacl Med Genom, Mexico City, DF, Mexico

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2016年 / 76卷 / 05期

基金：

美国国家卫生研究院;

关键词：

adaptive immunity; cytokines; maternal-fetal rejection; mouse; parturition; pregnancy; T cells; MATERNAL-FETAL INTERFACE; CHRONIC CHORIOAMNIONITIS; PREGNANCY COMPLICATIONS; CLINICAL-SIGNIFICANCE; UNKNOWN ETIOLOGY; LYMPHOCYTES-T; INFLAMMATION; TERM; PARTURITION; REJECTION;

D O I：

10.1111/aji.12562

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Problem: Activated/effector T cells seem to play a role in the pathological inflammation associated with preterm labor. The aim of this study was to determine whether in vivo T--cell activation by a monoclonal alpha CD3 epsilon antibody induces preterm labor and birth. Method of study: Pregnant B6 mice were intraperitoneally injected with a monoclonal alpha CD3 epsilon antibody or its isotype control. The gestational age, the rates of preterm birth and pup mortality at birth as well as the fetal heart rate and umbilical artery pulsatility index were determined. Results: Injection of a monoclonal aCD3e antibody led to preterm labor/birth (alpha CD3 epsilon 83 +/- 16.97% [10/12] vs isotype 0% [0/8]) and increased the rate of pup mortality at birth (alpha CD3 epsilon 87.30 +/- 8.95% [77/85] vs isotype 4.91 +/- 4.34% [3/59]). In addition, injection of a monoclonal alpha CD3 epsilon antibody decreased the fetal heart rate and increased the umbilical artery pulsatility index when compared to the isotype control. Conclusion: In vivo T-cell activation by a monoclonal alpha CD3 epsilon antibody in late gestation induces preterm labor and birth.

引用

页码：386 / 390

页数：5

共 48 条

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