Cu-Rh Redox Relay Catalysts for Synthesis of Azaheterocycles via C-H Functionalization

被引：83

作者：

Chiba, Shunsuke ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

CHEMISTRY LETTERS | 2012年 / 41卷 / 12期

关键词：

N BOND FORMATION; VINYL AZIDES; ALPHA; BETA-UNSATURATED KETOXIMES; RHODIUM(III)-CATALYZED SYNTHESIS; DIVERGENT SYNTHESIS; ALKYNES; IMINES; CYCLOPROPANOLS; ACTIVATION; ANNULATION;

D O I：

10.1246/cl.2012.1554

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This Highlight Review describes a Cu-Rh bimetallic redox relay catalytic system that enables efficient synthesis of highly substituted isoquinolines and their derivatives from readily available aryl ketoximes or alpha-arylvinyl azides with internal alkynes via C-H bond functionalization. A preliminary mechanistic investigation revealed that both the Cu and Rh catalysts are prerequisites to achieve the present process, and play their particular roles with synergistic cooperation during the multistep sequence.

引用

页码：1554 / 1559

页数：6

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