[1] Univ Paris Saclay, Drug Dev Dept DITEP, Gustave Roussy, Villejuif, France
[2] Ctr Leon Berard, Dept Med Oncol, Lyon, France
[3] Inst Claudius Regaud IUCT Oncopole, Toulouse, France
[4] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, Italy
[5] Humanitas Res Hosp, IRCCS, Rozzano, Italy
[6] Sorbonne Univ, AP HP, Univ Pitie Salpetriere Charles Foix,CNRS, Inst Cerveau,ICM,Serv Neurol, 2 Mazarin, F-75013 Paris, France
[7] Merck Co Inc, Rahway, NJ USA
[8] Univ Paris Saclay, Inst Natl Sante & Rech Med, Dept Innovat Therapeut & Essais Precoces, Gustave Roussy,U1015 CIC1428, Villejuif, France