Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

被引：11458

作者：

Gao, Jianjiong ^{[1
]}

Aksoy, Buelent Arman ^{[1
]}

Dogrusoz, Ugur ^{[2
]}

Dresdner, Gideon ^{[1
]}

Gross, Benjamin ^{[1
]}

Sumer, S. Onur ^{[1
]}

Sun, Yichao ^{[1
]}

Jacobsen, Anders ^{[1
]}

Sinha, Rileen ^{[1
]}

Larsson, Erik ^{[3
]}

Cerami, Ethan ^{[1
,4
]}

Sander, Chris ^{[1
]}

Schultz, Nikolaus ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Computat Biol Ctr, New York, NY 10065 USA

[2] Bilkent Univ, Dept Comp Engn, TR-06800 Ankara, Turkey

[3] Univ Gothenburg, Dept Med Biochem & Cell Biol, Inst Biomed, S-40530 Gothenburg, Sweden

[4] Blueprint Med, Cambridge, MA 02142 USA

来源：

SCIENCE SIGNALING | 2013年 / 6卷 / 269期

关键词：

NETWORK; MUTATIONS; CYTOSCAPE; PATHWAYS; TARGETS; BIOLOGY;

D O I：

10.1126/scisignal.2004088

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

引用

页数：19

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