Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies-Statement From ATVB Council

被引：220

作者：

Robinet, Peggy ^{[1
]}

Milewicz, Dianna M. ^{[2
]}

Cassis, Lisa A. ^{[3
]}

Leeper, Nicholas J. ^{[6
]}

Lu, Hong S. ^{[4
,5
]}

Smith, Jonathan D. ^{[1
]}

机构：

[1] Cleveland Clin, Dept Cellular & Mol Med, Box NC10,9500 Euclid Ave, Cleveland, OH 44195 USA

[2] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Internal Med, Div Med Genet, Houston, TX 77030 USA

[3] Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY USA

[4] Univ Kentucky, Saha Cardiovasc Res Ctr, Lexington, KY USA

[5] Univ Kentucky, Dept Physiol, Lexington, KY USA

[6] Stanford Univ, Dept Surg, Div Vasc Surg, Stanford, CA 94305 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2018年 / 38卷 / 02期

基金：

美国国家卫生研究院;

关键词：

animal models; aortic aneurysms; atherosclerosis; peripheral arterial disease; ABDOMINAL AORTIC-ANEURYSM; INTIMA-MEDIA THICKNESS; LDL RECEPTOR-DEFICIENT; GENDER-DIFFERENCES; RISK-FACTORS; INTERNATIONAL REGISTRY; CAROTID-ARTERY; ATHEROSCLEROTIC LESIONS; BRACHIOCEPHALIC ARTERY; MYOCARDIAL-INFARCTION;

D O I：

10.1161/ATVBAHA.117.309524

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are many differences in arterial diseases between men and women, including prevalence, clinical manifestations, treatments, and prognosis. The new policy of the National Institutes of Health, which requires the inclusion of sex as a biological variable for preclinical studies, aims to foster new mechanistic insights and to enhance our understanding of sex differences in human diseases. The purpose of this statement is to suggest guidelines for designing and reporting sex as a biological variable in animal models of atherosclerosis, thoracic and abdominal aortic aneurysms, and peripheral arterial disease. We briefly review sex differences of these human diseases and their animal models, followed by suggestions on experimental design and reporting of animal studies for these vascular pathologies.

引用

页码：292 / 303

页数：12

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