Synthesis, Characterization, Antimicrobial Activity and Molecular Docking Studies of New Benzimidazole, Benzoxazole, Imidazole and Tetrazole Derivatives

被引:1
作者
Arulmurugan, Subramaniyan [1 ]
Kavitha, Helen P. [1 ]
机构
[1] SRM Inst Sci & Technol, Dept Chem, Ramapuram Campus, Chennai 600089, Tamil Nadu, India
关键词
Benzoxazole; Benzimidazole; Imidazole; Tetrazole; Antimicrobial activity; Molecular docking; HIV-1; REVERSE-TRANSCRIPTASE; POTENT; BINDING; DESIGN;
D O I
10.13005/ojc/360411
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the present research work, 12 new compounds, such as benzimidazole (3, 3a-c), benzoxazole(4), imidazole(5, 5a-c) and tetrazole(6, 6a-c) were synthesized. FT-IR, Proton NMR (1H), C-13-NMR, Mass spectral values were used to prove the structures of the compounds. The antimicrobial potential of the representative compounds was assessed using the Disc diffusion process. All the benzoxazole, benzimidazole, imidazole and tetrazole derivatives prepared in this investigation show good antimicrobial activity. However the antimicrobial activities of the compounds are less compared with standard drugs. Molecular docking studies have also done for the synthesized compounds all the compounds show hydrogen bond interactions with receptor protein.
引用
收藏
页码:672 / 679
页数:8
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