Differences between coagulation and cytokine profiles in dogs of different ages

被引：15

作者：

Barthelemy, A. ^{[1
,2
]}

Rannou, B. ^{[3
]}

Forterre, M. ^{[1
,2
]}

Verwaerde, P. ^{[1
,4
]}

Bonnet-Garin, J. -M. ^{[2
]}

Pouzot-Nevoret, C. ^{[1
,2
]}

Goy-Thollot, I. ^{[1
,2
]}

机构：

[1] Univ Lyon, Intens Care Unit SIAMU, VetAgro Sup Campus Vet Lyon, Marcy Letoile, France

[2] Univ Lyon, Sepsis EA4174, VetAgro Sup Campus Vet Lyon, Inflammat,Hemostase, Marcy Letoile, France

[3] Univ Lyon, Lab Biol Med, VetAgro Sup Campus Vet Lyon, Marcy Letoile, France

[4] Vet Sch Toulouse, Crit & Intens Care & Anaesthesia, Toulouse, France

来源：

VETERINARY JOURNAL | 2015年 / 205卷 / 03期

关键词：

Ageing; Coagulation; Cytokines; Dog; Thromboelastometry; THROMBOELASTOMETRY; HYPERCOAGULABILITY;

D O I：

10.1016/j.tvjl.2015.05.012

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In human medicine, age is a risk factor for thromboembolic diseases associated with hypercoagulable and antifibrinolytic states, but information in veterinary medicine is limited. This study compared the thromboelastometric (TEM) profiles of two groups of dogs of distinct ages. Ten healthy old (>10 years) Beagles and 10 healthy young (<3 years) Beagles were recruited. White blood cell counts and haematocrit were significantly lower in the old group compared to the young group, and fibrinogen, total proteins, globulins and monocyte chemoattractant protein-1 plasma concentrations were significantly higher in the old group. Comparisons of the TEM profiles indicated a hypercoagulable profile and a decrease in fibrinolytic activity in all old Beagles. The findings support the need to consider age as a possible risk factor for thrombosis in dogs. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：410 / 412

页数：3

共 10 条

[1]

Barthelemy A., 2014, J VET EMERG CRIT CAR, V24, pS32

[2] The origins of age-related proinflammatory state [J].

Ferrucci, L ;

Corsi, A ;

Lauretani, F ;

Bandinelli, S ;

Bartali, B ;

Taub, DD ;

Guralnik, JM ;

Longo, DL .

BLOOD, 2005, 105 (06) :2294-2299

[3] Systematic evaluation of evidence on veterinary viscoelastic testing Part 2: Sample acquisition and handling [J].

Flatland, Bente ;

Koenigshof, Amy M. ;

Rozanski, Elizabeth A. ;

Goggs, Robert ;

Wiinberg, Bo .

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 2014, 24 (01) :30-36

[4] Increase in circulating levels of monocyte chemoattractant protein-1 with aging [J].

Inadera, H ;

Egashira, K ;

Takemoto, M ;

Ouchi, Y ;

Matsushima, K .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (10) :1179-1182

[5] HYPERCOAGULABILITY IN CENTENARIANS - THE PARADOX OF SUCCESSFUL AGING [J].

MARI, D ;

MANNUCCI, PM ;

COPPOLA, R ;

BOTTASSO, B ;

BAUER, KA ;

ROSENBERG, RD .

BLOOD, 1995, 85 (11) :3144-3149

[6] In vitro hypercoagulability on whole blood thromboelastometry associated with in vivo reduction of circulating red cell mass in dogs [J].

McMichael, Maureen A. ;

Smith, Stephanie A. ;

Galligan, Alyssa ;

Swanson, Kelly S. .

VETERINARY CLINICAL PATHOLOGY, 2014, 43 (02) :154-163

[7] Changes in thrombelastograph™ variables associated with aging [J].

Ng, KFJ .

ANESTHESIA AND ANALGESIA, 2004, 99 (02) :449-454

[8] In Normal Controls, Both Age and Gender Affect Coagulability as Measured by Thrombelastography [J].

Roeloffzen, Wilfried W. H. ;

Kluin-Nelemans, Hanneke C. ;

Mulder, Andre B. ;

Veeger, Nic J. G. M. ;

Bosman, Lotte ;

de Wolf, Joost Th. M. .

ANESTHESIA AND ANALGESIA, 2010, 110 (04) :987-994

[9] Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples [J].

Smith, Stephanie A. ;

McMichael, Maureen A. ;

Gilor, Shir ;

Galligan, Alyssa J. ;

Hob, Crystal M. .

AMERICAN JOURNAL OF VETERINARY RESEARCH, 2012, 73 (06) :789-798

[10] Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease [J].

Zois, Nora E. ;

Moesgaard, Sophia G. ;

Kjelgaard-Hansen, Mads ;

Rasmussen, Caroline E. ;

Falk, Torkel ;

Fossing, Christine ;

Haggstrom, Jens ;

Pedersen, Henrik D. ;

Olsen, Lisbeth H. .

VETERINARY JOURNAL, 2012, 192 (01) :106-111

← 1 →