Association between HBX status, aflatoxin-induced R249S TP53 mutation and risk of hepatocellular carcinoma in a case-control study from Thailand

被引：22
|
作者：
Ortiz-Cuaran, Sandra [1 ]
Villar, Stephanie [1 ]
Gouas, Doriane [1 ]
Ferro, Gilles [1 ]
Plymoth, Amelie [2 ]
Khuhaprema, Thiravud [3 ]
Kalalak, Anant [3 ]
Sangrajrang, Suleeporn [3 ]
Friesen, Marlin D. [4 ]
Groopman, John D. [4 ]
Hainaut, Pierre [1 ]
机构：
[1] Int Agcy Res Canc, F-69372 Lyon, France
[2] Karolinska Inst, Stockholm, Sweden
[3] Natl Canc Inst, Bangkok, Thailand
[4] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA
来源：
CANCER LETTERS | 2013年 / 331卷 / 01期
关键词：
R249S; Hepatitis B virus; Hepatocellularcarcinoma; HBX; HEPATITIS-B-VIRUS; X-PROTEIN; DEVELOPING-COUNTRIES; PATHOGENESIS; EXPOSURE; HEPATOCARCINOGENESIS; PROLIFERATION; INFECTIONS; ETIOLOGY; PLASMA;
D O I：
10.1016/j.canlet.2012.11.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation). Based on a case-control in Thailand, we have measured R249S and the status of HBX gene in plasma DNA of 176 cases and 133 referents. Detection of HBX complete sequences was associated with R249S in HCC with no documented prior cirrhosis but not in HCC developing in a context of cirrhosis or in non-cancer chronic liver diseases. Thus, R249S may specifically cooperate with HBX in a pathway to HCC that bypasses cirrhosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：46 / 51
页数：6
相关论文
共 50 条
  • [21] Inverse association between coffee drinking and the risk of hepatocellular carcinoma: a case-control study in Japan
    Tanaka, Keitaro
    Hara, Megumi
    Sakamoto, Tatsuhiko
    Higaki, Yasuki
    Mizuta, Toshihiko
    Eguchi, Yuichiro
    Yasutake, Tsutomu
    Ozaki, Iwata
    Yamamoto, Kyosuke
    Onohara, Shingo
    Kawazoe, Seiji
    Shigematsu, Hirohisa
    Koizumi, Shunzo
    CANCER SCIENCE, 2007, 98 (02) : 214 - 218
  • [22] Meta-analysis of association between the TP53 Arg72Pro polymorphism and risk of endometriosis based on case-control studies
    Yan, Yulan
    Wu, Renzheng
    Li, Shaojing
    He, Jinlong
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 2015, 189 : 1 - 7
  • [23] Association between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies
    Tian, Xin
    Dai, Shundong
    Sun, Jing
    Jiang, Shenyi
    Jiang, Youhong
    SCIENTIFIC REPORTS, 2016, 6
  • [24] Association between TP53 Arg72Pro polymorphism and leukemia risk: a meta-analysis of 14 case-control studies
    Xin Tian
    Shundong Dai
    Jing Sun
    Shenyi Jiang
    Youhong Jiang
    Scientific Reports, 6
  • [25] The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study (vol 22, 438, 2021)
    Montazeri-Najafabady, Nima
    Dabbaghmanesh, Mohammad Hossein
    Nasimi, Nasrin
    Sohrabi, Zahra
    Chatrabnous, Nazanin
    BMC MUSCULOSKELETAL DISORDERS, 2022, 23 (01)
  • [26] Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study
    Su, Chenghao
    Lin, Yong
    Cai, Lin
    Mao, Qianguo
    Niu, Jianjun
    SCIENTIFIC REPORTS, 2016, 6
  • [27] Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study
    Chenghao Su
    Yong Lin
    Lin Cai
    Qianguo Mao
    Jianjun Niu
    Scientific Reports, 6
  • [28] The association between rs2910164 in miR-146a and hepatocellular carcinoma risk: a case-control study
    Duan, Lei
    Wang, Wei-xing
    BIOMEDICAL RESEARCH-INDIA, 2017, 28 (11): : 5038 - 5040
  • [29] Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study
    Nene, Nuno R.
    Reisel, Daniel
    Leimbach, Andreas
    Franchi, Dorella
    Jones, Allison
    Evans, Iona
    Knapp, Susanne
    Ryan, Andy
    Ghozali, Shohreh
    Timms, John F.
    Paprotka, Tobias
    Bjorge, Line
    Zikan, Michal
    Cibula, David
    Colombo, Nicoletta
    Widschwendter, Martin
    LANCET ONCOLOGY, 2019, 20 (08): : 1171 - 1182
  • [30] A case-control study investigating the association of TP53 rs1042522 and CDH1 rs16260 polymorphisms with prostate cancer risk
    Akter, Rabeya
    Islam, Md Siddiqul
    Islam, Md Safiqul
    Aziz, Md Abdul
    Hussain, Md Saddam
    Millat, Md Shalahuddin
    Uddin, Mohammad Sarowar
    Islam, Mohammad Safiqul
    META GENE, 2021, 30
12345