A Peptoid Ribbon Secondary Structure

被引：103
作者：
Crapster, J. Aaron [1 ]
Guzei, Ilia A. [1 ]
Blackwell, Helen E. [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 19期
基金：
美国国家科学基金会;
关键词：
foldamers; peptidomimetics; peptoids; ribbons; secondary structure; SOLUTION CONFORMATION; PHASE SYNTHESIS; ION-CHANNEL; L-AMINO; OLIGOMERS; AMIDE; FOLDAMERS; PEPTIDE; GLYCINES); GEOMETRY;
D O I：
10.1002/anie.201208630
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Joining the fold: A series of peptoids, or oligomers of N-substituted glycines, adopt a novel secondary structure, designated the "peptoid ribbon". This fold was stable at short chain lengths and in a variety of solvents (both organic and aqueous), and arose from a primary sequence of peptoid monomers designed to enforce an alternating pattern of cis and trans main-chain amides. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：5079 / 5084
页数：6
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