Emc, a negative HLH regulator with multiple functions in Drosophila development

被引:38
作者
Campuzano, S [1 ]
机构
[1] Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain
关键词
Drosophila; extramacrochaetae; HLH; transcription factor; development;
D O I
10.1038/sj.onc.1205162
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Expression and functional analyses of Emc have demonstrated that it is a prototype for a protein required for multiple processes in development. Initially characterized as a negative regulator of sensory organ development, it was later found to regulate many other developmental processes and cell proliferation. Its ability to block the function of bRLH proteins by forming heterodimers, which are ineffective in DNA binding, accounts for the role of Emc in preventing the acquisition of several cell fates which are under the control of bHLH proteins. However, while maintaining this repressive molecular mechanism, emc also appears to act as a positive regulator of differentiation.
引用
收藏
页码:8299 / 8307
页数:9
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