Diagnosis and Assessment of Takayasu Arteritis by Multiple Biomarkers

被引:70
作者
Ishihara, Takashi [1 ]
Haraguchi, Go [1 ]
Tezuka, Daisuke [1 ]
Kamiishi, Tetsuo [1 ]
Inagaki, Hiroshi [1 ]
Isobe, Mitsuaki [1 ]
机构
[1] Tokyo Med & Dent Univ, Dept Cardiovasc Med, Tokyo 1138519, Japan
关键词
Biomarkers; Matrix metalloproteinase; Pentraxin3; Prednisolone; Takayasu arteritis; PENTRAXIN FAMILY; DISEASE-ACTIVITY; EXPRESSION; MARKER; PTX3;
D O I
10.1253/circj.CJ-12-0131
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Patients with Takayasu arteritis (TA) often show recurrence under steroid treatment without an elevation of C-reactive protein (CRP). There is a report that matrix metalloproteinase (MMP)-2, MMP-3, MMP-9 and pentraxin3 (PTX3) could be sensitive biomarkers, but the characteristics of these biomarkers have not been established. Methods and Results: We enrolled 45 consecutive patients; 28 were grouped in an active phase as evidenced by clinical recurrence within 2 years of blood sampling. Circulating levels of high-sensitivity (hs)CRP, MMPs, and PTX3 were determined. Patients in an active phase showed higher levels of hsCRP, MMP-9, and PTX3. Area under the receiving operating characteristics curves of hsCRP and PTX3 were significantly higher than that of MMP-9. Among the 28 patients with active TA, 71% was positive for hsCRP and 82% for PTX3. Patients without recurrence showed significantly higher plasma levels of MMP-9. There was a positive correlation between the plasma MMP-3 level and the prednisolone dose. However, PTX3 and MMP-9 levels did not have such a correlation. Conclusions: PTX3 and MMP-9, which are not affected by prednisolone, could be sensitive biomarkers for assessing TA activity. Evaluation of MMP-9 may suggest prior existence of TA. (Circ J 2013; 77: 477-483)
引用
收藏
页码:477 / 483
页数:7
相关论文
共 23 条
[1]  
ALLES VV, 1994, BLOOD, V84, P3483
[2]  
[Anonymous], 2008, CIRC J S4, V72, P1253
[3]  
AREND WP, 1990, ARTHRITIS RHEUM, V33, P1129
[4]   Is 18F-Fluorodeoxyglucose Positron Emission Tomography Scanning a Reliable Way to Assess Disease Activity in Takayasu Arteritis? [J].
Arnaud, Laurent ;
Haroche, Julien ;
Malek, Zoulikha ;
Archambaud, Frederique ;
Gambotti, Laetitia ;
Grimon, Gilles ;
Kas, Aurelie ;
Costedoat-Chalumeau, Nathalie ;
Cacoub, Patrice ;
Toledano, Dan ;
Cluzel, Philippe ;
Piette, Jean-Charles ;
Amoura, Zahir .
ARTHRITIS AND RHEUMATISM, 2009, 60 (04) :1193-1200
[5]   Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms [J].
Crowther, M ;
Goodall, S ;
Jones, JL ;
Bell, PRF ;
Thompson, MM .
JOURNAL OF VASCULAR SURGERY, 2000, 32 (03) :575-583
[6]   Pentraxin-3 as a Marker of Disease Activity in Takayasu Arteritis [J].
Dagna, Lorenzo ;
Salvo, Fulvio ;
Tiraboschi, Mirta ;
Bozzolo, Enrica P. ;
Franchini, Stefano ;
Doglioni, Claudio ;
Manfredi, Angelo A. ;
Baldissera, Elena ;
Sabbadini, Maria Grazia .
ANNALS OF INTERNAL MEDICINE, 2011, 155 (07) :425-U51
[7]   INTERSTITIAL COLLAGENASE (MMP-1), GELATINASE (MMP-2) AND STROMELYSIN (MMP-3) RELEASED BY HUMAN-FIBROBLASTS CULTURED ON ACELLULAR SARCOID GRANULOMAS (SARCOID MATRIX COMPLEX, SMC) [J].
EMONARD, H ;
TAKIYA, C ;
DREZE, S ;
CORDIER, JF ;
GRIMAUD, JA .
MATRIX, 1989, 9 (05) :382-388
[8]   Establishment of a high sensitivity plasma assay for human Pentraxin3 as a marker for unstable angina pectoris [J].
Inoue, Kenji ;
Sugiyama, Akira ;
Reid, Patrick C. ;
Ito, Yukio ;
Miyauchi, Katsumi ;
Mukai, Sei ;
Sagara, Mina ;
Miyamoto, Kyoko ;
Satoh, Hirokazu ;
Kohno, Isao ;
Kurata, Takeshi ;
Ota, Hiroshi ;
Mantovani, Alberto ;
Hamakubo, Takao ;
Daida, Hiroyuki ;
Kodama, Tatsuhiko .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (01) :161-167
[9]   Sensitive Assessment of Activity of Takayasu's Arteritis by Pentraxin3, a New Biomarker [J].
Ishihara, Takashi ;
Haraguchi, Go ;
Kamiishi, Tetsuo ;
Tezuka, Daisuke ;
Inagaki, Hiroshi ;
Isobe, Mitsuaki .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (16) :1712-1713
[10]   Increased Serum Pentraxin 3 in Patients with Systemic Sclerosis [J].
Iwata, Yohei ;
Yoshizaki, Ayumi ;
Ogawa, Fumihide ;
Komura, Kazuhiro ;
Hara, Toshihide ;
Muroi, Eiji ;
Takenaka, Motoi ;
Shimizu, Kazuhiro ;
Hasegawa, Minoru ;
Fujimoto, Manabu ;
Takehara, Kazuhiko ;
Sato, Shinichi .
JOURNAL OF RHEUMATOLOGY, 2009, 36 (05) :976-983