The Functional Properties of IgG4 and the IgG4-Related Diseases The Immunologist's Point of View

被引：0
作者：
Mueller-Hilke, B. [3 ]
Seidl, M. [2 ]
Peter, H. H. [1 ]
机构：
[1] Univ Med Ctr, CCI, D-79108 Freiburg, Germany
[2] Univ Klinikum Freiburg, Inst Pathol, Freiburg, Germany
[3] Univ Rostock, Inst Immunol, Rostock, Germany
来源：
AKTUELLE RHEUMATOLOGIE | 2012年 / 37卷 / 05期
关键词：
biology of IgG4; IgG4-related diseases; lymphoproliferation; FC-GAMMA RECEPTORS; AUTOIMMUNE PANCREATITIS; SCLEROSING PANCREATITIS; RETROPERITONEAL FIBROSIS; IMMUNOGLOBULIN G4; MIKULICZS-DISEASE; SYSTEMIC-DISEASE; T-CELLS; B-CELLS; AUTOANTIBODIES;
D O I：
10.1055/s-0032-1314831
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The IgG4 subclass accounts only for a small amount of total IgG (3-5%) and exhibits poor effector properties with regard to complement and FcRgamma activation. Yet since 10 years an increasing number of reports has defined a new set of IgG4-related diseases (IgG4-RD) characterised by elevated serum IgG4 levels and diffuse or nodular lympho-plasmocytic infiltrates (>40% IgG4+ plasma cells) in various, mainly exocrine organs. The infiltrates are typically associated with a chronic-fibrosing inflammation. While the serum IgG4+ fraction is not always increased it contains an increased proportion of various autoantibodies. Here we review the structural properties of the IgG4 molecule and the factors regulating class-switch to IgG4 and we discuss how the unique property of IgG4 to undergo Fab-arm exchange may influence the peripheral B cell tolerance and impact on the immunopathology of IgG4-RD.
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收藏
页码：288 / 294
页数：7
相关论文
共 65 条
  • [1] Immunoglobulin G4: an odd antibody
    Aalberse, R. C.
    Stapel, S. O.
    Schuurman, J.
    Rispens, T.
    [J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2009, 39 (04) : 469 - 477
  • [2] IGG SUBCLASSES IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND OTHER AUTOIMMUNE RHEUMATIC DISEASES
    BLANCO, F
    KALSI, J
    RAVIRAJAN, CT
    SPEIGHT, P
    BRADWELL, AR
    ISENBERG, DA
    [J]. LUPUS, 1992, 1 (06) : 391 - 399
  • [3] HUMAN-IGG ISOTYPE-SPECIFIC AMINO-ACID-RESIDUES AFFECTING COMPLEMENT-MEDIATED CELL-LYSIS AND PHAGOCYTOSIS
    BREKKE, OH
    MICHAELSEN, TE
    AASE, A
    SANDIN, RH
    SANDLIE, I
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (10) : 2542 - 2547
  • [4] BROUWER E, 1991, CLIN EXP IMMUNOL, V83, P379
  • [5] Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses
    Bruhns, Pierre
    Iannascoli, Bruno
    England, Patrick
    Mancardi, David A.
    Fernandez, Nadine
    Jorieux, Sylvie
    Daeron, Marc
    [J]. BLOOD, 2009, 113 (16) : 3716 - 3725
  • [6] THE BINDING-AFFINITY OF HUMAN-IGG FOR ITS HIGH-AFFINITY FC RECEPTOR IS DETERMINED BY MULTIPLE AMINO-ACIDS IN THE CH2 DOMAIN AND IS MODULATED BY THE HINGE REGION
    CANFIELD, SM
    MORRISON, SL
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (06) : 1483 - 1491
  • [7] Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis
    Cao, D
    Malmström, V
    Baecher-Allan, C
    Hafler, D
    Klareskog, L
    Trollmo, C
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (01) : 215 - 223
  • [8] Therapeutic antibodies for autoimmunity and inflammation
    Chan, Andrew C.
    Carter, Paul J.
    [J]. NATURE REVIEWS IMMUNOLOGY, 2010, 10 (05) : 301 - 316
  • [9] Lymphadenopathy of IgG4-related sclerosing disease
    Cheuk, Wah
    Yuen, Hunter K. L.
    Chu, Stephenie Y. Y.
    Chiu, Edinond K. W.
    Lam, L. K.
    Chan, John K. C.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2008, 32 (05) : 671 - 681
  • [10] IgG4-related Sclerosing Mastitis: Description of a New Member of the IgG4-related Sclerosing Diseases
    Cheuk, Wah
    Chan, Alexander C. L.
    Lam, Wai-Lung
    Chow, Sheung-Ming
    Crowley, Peter
    Lloydd, Richard
    Campbell, Ian
    Thorburn, Murray
    Chan, John K. C.
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2009, 33 (07) : 1058 - 1064
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