Second Malignant Neoplasms Following Radiotherapy

被引：85
作者：
Kumar, Sanath [1 ]
机构：
[1] Henry Ford Hosp, Dept Radiat Oncol, Detroit, MI 48202 USA
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2012年 / 9卷 / 12期
关键词：
radiation; second malignancy; cancer therapy; side effects; radiotherapy; neoplasm; LONG-TERM SURVIVORS; CHILDHOOD-CANCER; BREAST-CANCER; SUBSEQUENT NEOPLASMS; CONTRALATERAL BREAST; SECONDARY NEUTRONS; RADIATION-THERAPY; 5-YEAR SURVIVORS; HODGKINS-DISEASE; SOLID CANCER;
D O I：
10.3390/ijerph9124744
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
More than half of all cancer patients receive radiotherapy as a part of their treatment. With the increasing number of long-term cancer survivors, there is a growing concern about the risk of radiation induced second malignant neoplasm [SMN]. This risk appears to be highest for survivors of childhood cancers. The exact mechanism and dose-response relationship for radiation induced malignancy is not well understood, however, there have been growing efforts to develop strategies for the prevention and mitigation of radiation induced cancers. This review article focuses on the incidence, etiology, and risk factors for SMN in various organs after radiotherapy.
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收藏
页码：4744 / 4759
页数：16
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