Iridium-Catalyzed Oxidant-Free Dehydrogenative C-H Bond Functionalization: Selective Preparation of N-Arylpiperidines through Tandem Hydrogen Transfers

被引：111

作者：

Yuan, Kedong

Jiang, Fan

Sahli, Zeyneb

Achard, Mathieu

Roisnel, Thierry ^{[1
]}

Bruneau, Christian ^{[1
]}

机构：

[1] Univ Rennes, Inst Sci Chim Rennes, CNRS UMR6226, Ctr Diffractometrie X, F-35042 Rennes, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 35期

关键词：

dehydrogenation; heterocycles; hydrogen transfer; iridium; synthetic methods; BORROWING HYDROGEN; TERTIARY-AMINES; SECONDARY ALCOHOLS; HETEROCYCLIC CARBENE; ALPHA-ALKYLATION; BETA-ALKYLATION; RUTHENIUM; AMINATION; COMPLEXES; COPOLYMERIZATION;

D O I：

10.1002/anie.201204582

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Relay to the finish: The atom-economical tandem hydrogen autotransfer catalyzed by iridium(III) has been efficiently applied for the preparation of N-arylpiperidines starting from easily accessible anilines, diols, and aldehydes (see scheme). This protocol is also compatible with the use of diethyl carbonate as an ecofriendly solvent. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8876 / 8880

页数：5

共 98 条

[1] Selective Alkylation of (Hetero)Aromatic Amines with Alcohols Catalyzed by a Ruthenium Pincer Complex [J].