White matter correlates of the disorganized speech dimension in schizophrenia

被引：16

作者：

Viher, Petra V. ^{[1
]}

Stegmayer, Katharina ^{[1
]}

Giezendanner, Stephanie ^{[1
]}

Federspiel, Andrea ^{[1
]}

Bohlhalter, Stephan ^{[2
,3
]}

Wiest, Roland ^{[4
]}

Strik, Werner ^{[1
]}

Walther, Sebastian ^{[1
]}

机构：

[1] Univ Hosp Psychiat, Translat Res Ctr, Bolligenstr 111, CH-3000 Bern 60, Switzerland

[2] Inselspital Bern, Dept Clin Res, Bern, Switzerland

[3] Luzerner Kantonsspital, Neurol & Neurorehabil Ctr, Luzern, Switzerland

[4] Inselspital Bern, SCAN, Univ Inst Diagnost & Intervent Neuroradiol, Bern, Switzerland

来源：

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | 2018年 / 268卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

Formal thought disorders; Language system; Bern Psychopathology Scale; Diffusion tensor imaging; Tract-based spatial statistics; FORMAL THOUGHT-DISORDER; BERN PSYCHOPATHOLOGY SCALE; NEGATIVE SYNDROME SCALE; ATYPICAL ANTIPSYCHOTICS; LANGUAGE; ABNORMALITIES; SYSTEM; BRAIN; TRACTOGRAPHY; HYPOTHESIS;

D O I：

10.1007/s00406-016-0753-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Disorganized speech is related to functional abnormalities in schizophrenia. To test the association between formal thought disorders (FTDs) and white matter microstructure, we applied a behavioral rating and diffusion tensor imaging in 61 patients with schizophrenia spectrum disorders. The Bern Psychopathology Scale was used to rate the dimension of language abnormalities ranging from negative FTDs, basically unaltered speech, to positive FTDs. Tract-based spatial statistics indicated increased fractional anisotropy in left hemispheric pathways of the language system in patients with negative FTDs. Thus, altered white matter properties in relevant fiber tracts may represent vulnerability to specific formal thought disorders.

引用

页码：99 / 104

页数：6

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