Combating chronic T-cell exhaustion

被引：0

作者：

McAfee, Megan S. ^{[1
]}

Blattman, Joseph N. ^{[1
]}

机构：

[1] Arizona State Univ, Ctr Infect Dis & Vaccinol, Biodesign Inst, Tempe, AZ 85253 USA

来源：

IMMUNOTHERAPY | 2012年 / 4卷 / 06期

关键词：

cancer; cytokines; exhaustion; immunotherapy; infection; inhibition; T cell; tolerance; CHRONIC VIRAL-INFECTION; IN-VIVO; ADOPTIVE IMMUNOTHERAPY; INHIBITORY RECEPTORS; PD-1; EXPRESSION; UP-REGULATION; PERSISTENCE; TIM-3; AUTOIMMUNITY; RESPONSES;

D O I：

10.2217/IMT.12.46

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：557 / 560

页数：4

共 39 条

[1] Viral escape from dominant simian immunodeficiency virus epitope-specific cytotoxic T lymphocytes in DNA-vaccinated rhesus monkeys [J].

Barouch, DH ;

Kunstman, J ;

Glowczwskie, J ;

Kunstman, KJ ;

Egan, MA ;

Peyerl, FW ;

Santra, S ;

Kuroda, MJ ;

Schmitz, JE ;

Beaudry, K ;

Krivulka, GR ;

Lifton, MA ;

Gorgone, DA ;

Wolinsky, SM ;

Letvin, NL .

JOURNAL OF VIROLOGY, 2003, 77 (13) :7367-7375

[2] Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+T Cells Is Linked to Antigen Recognition and T Cell Differentiation [J].

Bengsch, Bertram ;

Seigel, Bianca ;

Ruhl, Marianne ;

Timm, Joerg ;

Kuntz, Martin ;

Blum, Hubert E. ;

Pircher, Hanspeter ;

Thimme, Robert .

PLOS PATHOGENS, 2010, 6 (06)

[3] IL-10, T cell exhaustion and viral persistence [J].

Blackburn, Shawn D. ;

Wherry, E. John .

TRENDS IN MICROBIOLOGY, 2007, 15 (04) :143-146

[4] Tissue-Specific Differences in PD-1 and PD-L1 Expression during Chronic Viral Infection: Implications for CD8 T-Cell Exhaustion [J].

Blackburn, Shawn D. ;

Crawford, Alison ;

Shin, Haina ;

Polley, Antonio ;

Freeman, Gordon J. ;

Wherry, E. John .

JOURNAL OF VIROLOGY, 2010, 84 (04) :2078-2089

[5] Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection [J].

Blackburn, Shawn D. ;

Shin, Haina ;

Haining, W. Nicholas ;

Zou, Tao ;

Workman, Creg J. ;

Polley, Antonio ;

Betts, Michael R. ;

Freeman, Gordon J. ;

Vignali, Dario A. A. ;

Wherry, E. John .

NATURE IMMUNOLOGY, 2009, 10 (01) :29-37

[6] Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo [J].

Blattman, JN ;

Grayson, JM ;

Wherry, EJ ;

Kaech, SM ;

Smith, KA ;

Ahmed, R .

NATURE MEDICINE, 2003, 9 (05) :540-547

[7] IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection [J].

Brooks, David G. ;

Ha, Sang-Jun ;

Elsaesser, Heidi ;

Sharpe, Arlene H. ;

Freeman, Gordon J. ;

Oldstone, Michael B. A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20428-20433

[8] Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection [J].

Butler, Noah S. ;

Moebius, Jacqueline ;

Pewe, Lecia L. ;

Traore, Boubacar ;

Doumbo, Ogobara K. ;

Tygrett, Lorraine T. ;

Waldschmidt, Thomas J. ;

Crompton, Peter D. ;

Harty, John T. .

NATURE IMMUNOLOGY, 2012, 13 (02) :188-195

[9]

Carroll L., 1871, Through the Looking-Glass, and What Alice Found There

[10] PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression [J].

Day, Cheryl L. ;

Kaufmann, Daniel E. ;

Kiepiela, Photini ;

Brown, Julia A. ;

Moodley, Eshia S. ;

Reddy, Sharon ;

Mackey, Elizabeth W. ;

Miller, Joseph D. ;

Leslie, Alasdair J. ;

DePierres, Chantal ;

Mncube, Zenele ;

Duraiswamy, Jaikumar ;

Zhu, Baogong ;

Eichbaum, Quentin ;

Altfeld, Marcus ;

Wherry, E. John ;

Coovadia, Hoosen M. ;

Goulder, Philip J. R. ;

Klenerman, Paul ;

Ahmed, Rafi ;

Freeman, Gordon J. ;

Walker, Bruce D. .

NATURE, 2006, 443 (7109) :350-354

← 1 2 3 4 →