Towards Recyclable NAD(P)H Regeneration Catalysts

被引：26
|
作者：
de Torres, Miriam [2 ]
Dimroth, Jonas [3 ]
Arends, Isabel W. C. E. [1 ]
Keilitz, Juliane [4 ]
Hollmann, Frank [1 ]
机构：
[1] Delft Univ Technol, Dept Biotechnol, NL-2628 BL Delft, Netherlands
[2] Univ Zaragoza, Dept Quim Organ, E-50009 Zaragoza, Spain
[3] Tech Univ Berlin, Dept Chem, D-10623 Berlin, Germany
[4] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
来源：
MOLECULES | 2012年 / 17卷 / 08期
关键词：
biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts; ASYMMETRIC TRANSFER HYDROGENATION; ARTIFICIAL PHOTOSYNTHESIS; CHEMOENZYMATIC REDUCTION; NICOTINAMIDE; EFFICIENT; LIQUIDS; DRIVEN;
D O I：
10.3390/molecules17089835
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)](2+) was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.
引用
收藏
页码：9835 / 9841
页数：7
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