Towards Recyclable NAD(P)H Regeneration Catalysts

被引：26

作者：

de Torres, Miriam ^{[2
]}

Dimroth, Jonas ^{[3
]}

Arends, Isabel W. C. E. ^{[1
]}

Keilitz, Juliane ^{[4
]}

Hollmann, Frank ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, NL-2628 BL Delft, Netherlands

[2] Univ Zaragoza, Dept Quim Organ, E-50009 Zaragoza, Spain

[3] Tech Univ Berlin, Dept Chem, D-10623 Berlin, Germany

[4] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

MOLECULES | 2012年 / 17卷 / 08期

关键词：

biocatalysis; cofactor regeneration; chemoenzymatic cascades; immobilized catalysts; ASYMMETRIC TRANSFER HYDROGENATION; ARTIFICIAL PHOTOSYNTHESIS; CHEMOENZYMATIC REDUCTION; NICOTINAMIDE; EFFICIENT; LIQUIDS; DRIVEN;

D O I：

10.3390/molecules17089835

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)](2+) was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is proposed, which may overcome some of the current limitations such as catalyst cost and incompatibility of Rh with some biocatalysts.

引用

页码：9835 / 9841

页数：7

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