cGMP Signaling in Cardiovascular Diseases: Linking Genotype and Phenotype

被引：17

作者：

Dang, Tan An ^{[1
]}

Schunkert, Heribert ^{[1
,2
]}

Kessler, Thorsten ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klin Herz & Kreislauferkrankungen, Deutsch Herzzentrum Munchen, Lazarettstr 36, D-80636 Munich, Germany

[2] Deutsch Zentrum Herz Kreislauf Forsch DZHK eV, Partnersite Munich Heart Alliance, Munich, Germany

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2020年 / 75卷 / 06期

关键词：

cardiovascular diseases; coronary artery disease; myocardial infarction; genetics; genome-wide association studies; cGMP; NITRIC-OXIDE SYNTHASE; SOLUBLE GUANYLATE-CYCLASE; GENOME-WIDE ASSOCIATION; CYCLIC ADENINE RIBONUCLEOTIDE; CHRONIC HEART-FAILURE; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; PLATELET-AGGREGATION; PULMONARY-HYPERTENSION; PHOSPHOPROTEIN VASP;

D O I：

10.1097/FJC.0000000000000744

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cyclic guanosine 3 ',5 '-monophosphate (cGMP) is the key second messenger molecule in nitric oxide signaling. Its rapid generation and fate, but also its role in mediating acute cellular functions has been extensively studied. In the past years, genetic studies suggested an important role for cGMP in affecting the risk of chronic cardiovascular diseases, for example, coronary artery disease and myocardial infarction. Here, we review the role of cGMP in atherosclerosis and other cardiovascular diseases and discuss recent genetic findings and identified mechanisms. Finally, we highlight open questions and promising research topics.

引用

页码：516 / 525

页数：10

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